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MAN1B1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1278083 MAN1B1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAN1B1, cDNA Clone

★Popular Item★
 Also Known As   

MAN1B1 cDNA Clone

 Product Gene Name   

MAN1B1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggctgcct gcgagggcag gagaagcgga gctctcggtt cctctcagtc ggacttcctg acgccgccag tgggcggggc cccttgggcc gtcgccacca ctgtagtcat gtacccaccg ccgccgccgc cgcctcatcg ggacttcatc tcggtgacgc tgagctttgg cgagagctat gacaacagca agagttggcg gcggcgctcg tgctggagga aatggaagca actgtcgaga ttgcagcgga atatgattct cttcctcctt gcctttctgc ttttctgtgg actcctcttc tacatcaact tggctgacca ttggaaagct ctggctttca ggctagagga agagcagaag atgaggccag aaattgctgg gttaaaacca gcaaatccac ccgtcttacc agctcctcag aaggcggaca ccgaccctga gaacttacct gagatttcgt cacagaagac acaaagacac atccagcggg gaccacctca cctgcagatt agacccccaa gccaagacct gaaggatggg acccaggagg aggccacaaa aaggcaagaa gcccctgtgg atccccgccc ggaaggagat ccgcagagga cagtcatcag ctggagggga gcggtgatcg agcctgagca gggcaccgag ctcccttcaa gaagagcaga agtgcccacc aagcctcccc tgccaccggc caggacacag ggcacaccag tgcatctgaa ctatcgccag aagggcgtga ttgacgtctt cctgcatgca tggaaaggat accgcaagtt tgcatggggc catgacgagc tgaagcctgt gtccaggtcc ttcagtgagt ggtttggcct cggtctcaca ctgatcgacg cgctggacac catgtggatc ttgggtctga ggaaagaatt tgaggaagcc aggaagtggg tgtcgaagaa gttacacttt gaaaaggacg tggacgtcaa cctgtttgag agcacgatcc gcatcctggg ggggctcctg agtgcctacc acctgtctgg ggacagcctc ttcctgagga aagctgagga ttttggaaat cggctaatgc ctgccttcag aacaccatcc aagattcctt actcggatgt gaacatcggt actggagttg cccacccgcc acggtggacc tccgacagca ctgtggccga ggtgaccagc attcagctgg agttccggga gctctcccgt ctcacagggg ataagaagtt tcaggaggca gtggagaagg tgacacagca catccacggc ctgtctggga agaaggatgg gctggtgccc atgttcatca atacccacag tggcctcttc acccacctgg gcgtattcac gctgggcgcc agggccgaca gctactatga gtacctgctg aagcagtgga tccagggcgg gaagcaggag acacagctgc tggaagacta cgtggaagcc atcgagggtg tcagaacgca cctgctgcgg cactccgagc ccagtaagct cacctttgtg ggggagcttg cccacggccg cttcagtgcc aagatggacc acctggtgtg cttcctgcca gggacgctgg ctctgggcgt ctaccacggc ctgcccgcca gccacatgga gctggcccag gagctcatgg agacttgtta ccagatgaac cggcagatgg agacggggct gagtcccgag atcgtgcact tcaaccttta cccccagccg ggccgtcggg acgtggaggt caagccagca gacaggcaca acctgctgcg gccagagacc gtggagagcc tgttctacct gtaccgcgtc acaggggacc gcaaatacca ggactggggc tgggagattc tgcagagctt cagccgattc acacgggtcc cctcgggtgg ctattcttcc atcaacaatg tccaggatcc tcagaagccc gagcctaggg acaagatgga gagcttcttc ctgggggaga cgctcaagta tctgttcttg ctcttctccg atgacccaaa cctgctcagc ctggatgcct acgtgttcaa caccgaagcc caccctctgc ctatctggac ccctgcctag
 OMIM    604346
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MAN1B1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MAN1B1. It may not necessarily be applicable to this product.
 NCBI GI #    12804190
 NCBI GeneID    11253
 NCBI Accession #    BC002953 [Other Products]
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 UniProt Secondary Accession #    Q5VSG3; Q9BRS9; Q9Y5K7 [Other Products]
 UniProt Related Accession #    Q9UKM7 [Other Products]
 Molecular Weight    79,580 Da
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 NCBI Official Full Name    Homo sapiens mannosidase, alpha, class 1B, member 1, mRNA
 NCBI Official Synonym Full Names    mannosidase alpha class 1B member 1
 NCBI Official Symbol    MAN1B1 [Similar Products]
 NCBI Official Synonym Symbols   
MRT15; ERMAN1; ERManI; MANA-ER
[Similar Products]
 NCBI Protein Information    endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
 UniProt Protein Name    Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
 UniProt Synonym Protein Names   
ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1
 Protein Family    Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
 UniProt Gene Name    MAN1B1 [Similar Products]
 UniProt Synonym Gene Names    ERMan1 [Similar Products]
 UniProt Entry Name    MA1B1_HUMAN
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 NCBI Summary for MAN1B1    This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
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 UniProt Comments for MAN1B1    MAN1B1: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the glycosyl hydrolase 47 family.

Protein type: Calcium-binding; EC 3.2.1.113; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane

Molecular Function: alpha-mannosidase activity; calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Biological Process: ER-associated protein catabolic process; N-glycan processing; oligosaccharide metabolic process

Disease: Mental Retardation, Autosomal Recessive 15
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 Research Articles on MAN1B1    1. Data show that HIV-1 env protein interacts with alpha-mannosidases ERManI (MAN1B1) and initiates endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway degradation process.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MAN1B1 cdna cloneDiseases associated with MAN1B1 cdna clone
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 ER Quality Control Compartment (ERQC) Pathway antibodies  ER Quality Control Compartment (ERQC) Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Precursor Trimming Pathway antibodies  N-glycan Precursor Trimming Pathway Diagram
 N-glycan Precursor Trimming Pathway antibodies  N-glycan Precursor Trimming Pathway Diagram
 N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway antibodies  N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with MAN1B1 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with MAN1B1 and Liver Diseases
Organs/Tissues associated with MAN1B1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with MAN1B1 and Liver
 Brain Antibodies  >1 publications with MAN1B1 and Brain
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