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MAP1LC3B cdna clone

Scan QR to view Datasheet Catalog #    MBS1275159 MAP1LC3B cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP1LC3B, cDNA Clone

★Popular Item★
 Also Known As   


 Product Gene Name   

MAP1LC3B cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 OMIM    609604
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MAP1LC3B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MAP1LC3B. It may not necessarily be applicable to this product.
 NCBI GI #    28374393
 NCBI GeneID    81631
 NCBI Accession #    BC045759 [Other Products]
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 UniProt Secondary Accession #    Q6NW02 [Other Products]
 UniProt Related Accession #    Q9GZQ8 [Other Products]
 Molecular Weight    14,688 Da
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 NCBI Official Full Name    Homo sapiens microtubule-associated protein 1 light chain 3 beta, mRNA
 NCBI Official Synonym Full Names    microtubule associated protein 1 light chain 3 beta
 NCBI Official Symbol    MAP1LC3B [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    microtubule-associated proteins 1A/1B light chain 3B
 UniProt Protein Name    Microtubule-associated proteins 1A/1B light chain 3B
 UniProt Synonym Protein Names   
Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta
 Protein Family    Microtubule-associated protein
 UniProt Gene Name    MAP1LC3B [Similar Products]
 UniProt Synonym Gene Names    MAP1ALC3; MAP1A/MAP1B LC3 B [Similar Products]
 UniProt Entry Name    MLP3B_HUMAN
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 NCBI Summary for MAP1LC3B    The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAP1LC3B    LC3B: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Recruits proteins such as SQSTM1 and NBR1 to the autophagosome.

Protein type: Ubiquitin-like modifier; Vesicle; Microtubule-binding; Autophagy

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: autophagic vacuole; axoneme; cytosol; intracellular; mitochondrion

Molecular Function: microtubule binding; protein binding; ubiquitin protein ligase binding

Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy
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 Research Articles on MAP1LC3B    1. In microsatellite stable carcinomas, the level of LC3B-II expression was higher than that in the microsatellite unstable carcinomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MAP1LC3B cdna cloneDiseases associated with MAP1LC3B cdna clone
 Products by Pathway  Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >21 publications with MAP1LC3B and Neoplasms
 Carcinoma Antibodies  >8 publications with MAP1LC3B and Carcinoma
 Breast Neoplasms Antibodies  >7 publications with MAP1LC3B and Breast Neoplasms
 Adenocarcinoma Antibodies  >5 publications with MAP1LC3B and Adenocarcinoma
 Nervous System Diseases Antibodies  >5 publications with MAP1LC3B and Nervous System Diseases
 Necrosis Antibodies  >4 publications with MAP1LC3B and Necrosis
 Drug Toxicity Antibodies  >2 publications with MAP1LC3B and Drug Toxicity
 Kidney Diseases Antibodies  >2 publications with MAP1LC3B and Kidney Diseases
 Lung Neoplasms Antibodies  >2 publications with MAP1LC3B and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with MAP1LC3B and Ovarian Neoplasms
Organs/Tissues associated with MAP1LC3B cdna clone
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with MAP1LC3B and Lung
 Blood Antibodies  >5 publications with MAP1LC3B and Blood
 Skin Antibodies  >4 publications with MAP1LC3B and Skin
 Kidney Antibodies  >4 publications with MAP1LC3B and Kidney
 Brain Antibodies  >4 publications with MAP1LC3B and Brain
 Eye Antibodies  >3 publications with MAP1LC3B and Eye
 Muscle Antibodies  >3 publications with MAP1LC3B and Muscle
 Embryonic Tissue Antibodies  >2 publications with MAP1LC3B and Embryonic Tissue
 Lymph Node Antibodies  >2 publications with MAP1LC3B and Lymph Node
 Lymph Antibodies  >2 publications with MAP1LC3B and Lymph
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