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MDM4 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275346 MDM4 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MDM4, cDNA Clone

★Popular Item★
 Also Known As   

MDM4 cDNA Clone

 Product Gene Name   

MDM4 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgacatcat tttccacctc tgctcagtgt tcaacatctg acagtgcttg caggatctct cctggacaaa tcaatcaggt acgaccaaaa ctgccgcttt tgaagatttt gcatgcagca ggtgcgcaag gtgaaatgtt cactgttaaa gaggtcatgc actatttagg tcagtacata atggtgaagc aactttatga tcagcaggag cagcatatgg tatattgtgg tggagatctt ttgggagaac tactgggacg tcagagcttc tccgtgaaag acccaagccc tctctatgat atgctaagaa agaatcttgt cactttagcc actgctacta cagatgctgc tcagactctc gctctcgcac aggatcacag tatggatatt ccaagtcaag accaactgaa gcaaagtgca gaggaaagtt ccacttccag aaaaagaact acagaagacg atatccccac actgcctacc tcagagcata aatgcataca ttctagagaa gatgaagact taattgaaaa tttagcccaa gatgaaacat ctaggctgga ccttggattt gaggagtggg atgtagctgg cctgccttgg tggtttttag gaaacttgag aagcaactat acacctagaa gtaatggctc aactgattta cagacaaatc aggatgtggg tactgccatt gtttcagata ctacagatga cttgtggttt ttgaatgagt cagtatcaga gcagttaggt gttggaataa aagttgaagc tgctgatact gaacaaacaa gtgaagaagt agggaaagta agtgacaaaa aggtgattga agtgggaaaa aatgatgacc tggaggactc taagtcctta agtgatgata ccgatgtaga ggttacctct gaggatgagt ggcagtgtac tgaatgcaag aaatttaact ctccaagcaa gaggtactgt tttcgttgtt gggccttgag gaaggattgg tattcagatt gttcaaagtt aacccattct ctctccacgt ctgatatcac tgccatacct gaaaaggaaa atgaaggaaa tgatgtccct gattgtcgaa gaaccatttc ggctcctgtc gttagaccta aagatgcgta tataaagaaa gaaaactcca aactttttga tccctgcaac tcagtggaat tcttggattt ggctcacagt tctgaaagcc aagagaccat ctcaagcatg ggagaacagt tagataacct ttctgaacag agaacagata cagaaaacat ggaggattgc cagaatctct tgaagccatg tagcttatgt gagaaaagac cacgagacgg gaacattatt catggaagga cgggccatct tgtcacttgt tttcactgtg ccagaagact aaagaaggct ggggcttcat gccctatttg caagaaagag attcagctgg ttattaaggt ttttatagca taa
 OMIM    602704
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MDM4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MDM4. It may not necessarily be applicable to this product.
 NCBI GI #    45501364
 NCBI GeneID    4194
 NCBI Accession #    BC067299 [Other Products]
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 UniProt Secondary Accession #    Q2M2Y2; Q32SL2; Q6GS18; Q8IV83 [Other Products]
 UniProt Related Accession #    O15151 [Other Products]
 Molecular Weight    49,541 Da
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 NCBI Official Full Name    Homo sapiens Mdm4 p53 binding protein homolog (mouse), mRNA
 NCBI Official Synonym Full Names    MDM4, p53 regulator
 NCBI Official Symbol    MDM4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein Mdm4
 UniProt Protein Name    Protein Mdm4
 UniProt Synonym Protein Names   
Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
 Protein Family    Protein
 UniProt Gene Name    MDM4 [Similar Products]
 UniProt Synonym Gene Names    MDMX [Similar Products]
 UniProt Entry Name    MDM4_HUMAN
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 NCBI Summary for MDM4    This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
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 UniProt Comments for MDM4    MDM4: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53. Down-regulated by cisplatin. Expressed in all tissues tested with high levels in thymus. Belongs to the MDM2/MDM4 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: nucleoplasm; nucleus

Molecular Function: enzyme binding; protein binding; zinc ion binding

Biological Process: cell proliferation; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G0 to G1 transition; negative regulation of cell proliferation; negative regulation of protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; protein complex assembly; protein stabilization
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 Research Articles on MDM4    1. CETSA was able to validate stapled peptide binding to Mdm2 and Mdm4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MDM4 cdna cloneDiseases associated with MDM4 cdna clone
 Products by Pathway  Pathway Diagram
 Signaling Pathways In Glioblastoma antibodies  Signaling Pathways In Glioblastoma Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >129 publications with MDM4 and Neoplasms
 Neoplasms, Experimental Antibodies  >15 publications with MDM4 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >14 publications with MDM4 and Nervous System Diseases
 Breast Neoplasms Antibodies  >14 publications with MDM4 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >13 publications with MDM4 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >9 publications with MDM4 and Adenocarcinoma
 Glioblastoma Antibodies  >7 publications with MDM4 and Glioblastoma
 Ovarian Neoplasms Antibodies  >4 publications with MDM4 and Ovarian Neoplasms
 Heart Diseases Antibodies  >4 publications with MDM4 and Heart Diseases
 Liver Diseases Antibodies  >3 publications with MDM4 and Liver Diseases
Organs/Tissues associated with MDM4 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with MDM4 and Brain
 Embryonic Tissue Antibodies  >11 publications with MDM4 and Embryonic Tissue
 Bone Antibodies  >10 publications with MDM4 and Bone
 Eye Antibodies  >9 publications with MDM4 and Eye
 Liver Antibodies  >8 publications with MDM4 and Liver
 Lung Antibodies  >8 publications with MDM4 and Lung
 Blood Antibodies  >8 publications with MDM4 and Blood
 Bone Marrow Antibodies  >7 publications with MDM4 and Bone Marrow
 Muscle Antibodies  >6 publications with MDM4 and Muscle
 Thyroid Antibodies  >5 publications with MDM4 and Thyroid
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