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MGEA5 cdna clone

Scan QR to view Datasheet Catalog #    MBS1271856 MGEA5 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MGEA5, cDNA Clone

 Also Known As   

MGEA5 cDNA Clone

 Product Gene Name   

MGEA5 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    604039
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MGEA5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MGEA5. It may not necessarily be applicable to this product.
 NCBI GI #    34192982
 NCBI GeneID    10724
 NCBI Accession #    BC039583 [Other Products]
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 UniProt Secondary Accession #    O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0; B7WPB9; D3DR79; E9PGF9 [Other Products]
 UniProt Related Accession #    O60502 [Other Products]
 Molecular Weight    96,932 Da
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 NCBI Official Full Name    Homo sapiens meningioma expressed antigen 5 (hyaluronidase), mRNA
 NCBI Official Synonym Full Names    meningioma expressed antigen 5 (hyaluronidase)
 NCBI Official Symbol    MGEA5 [Similar Products]
 NCBI Official Synonym Symbols   
OGA; MEA5; NCOAT
[Similar Products]
 NCBI Protein Information    protein O-GlcNAcase
 UniProt Protein Name    Protein O-GlcNAcase
 UniProt Synonym Protein Names   
Beta-N-acetylglucosaminidase
 Protein Family    Protein O-GlcNAcase
 UniProt Gene Name    MGEA5 [Similar Products]
 UniProt Synonym Gene Names    HEXC; KIAA0679; MEA5; NCOAT [Similar Products]
 UniProt Entry Name    OGA_HUMAN
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 NCBI Summary for MGEA5    The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for MGEA5    OGA: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.52; EC 3.2.1.169; Hydrolase; Acetyltransferase

Chromosomal Location of Human Ortholog: 10q24.1-q24.3

Cellular Component: cytosol; membrane

Molecular Function: beta-N-acetylglucosaminidase activity; hyalurononglucosaminidase activity

Biological Process: glycoprotein catabolic process; N-acetylglucosamine metabolic process; protein deglycosylation
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 Research Articles on MGEA5    1. E2F1 negatively regulates both Ogt and Mgea5 expression in an Rb1 protein-dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with MGEA5 cdna cloneOrgans/Tissues associated with MGEA5 cdna clone
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with MGEA5 and Inflammation
 Kidney Diseases Antibodies  >3 publications with MGEA5 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with MGEA5 and Blood
 Bladder Antibodies  >3 publications with MGEA5 and Bladder
 Kidney Antibodies  >3 publications with MGEA5 and Kidney
 Vascular Antibodies  >2 publications with MGEA5 and Vascular
 Skin Antibodies  >2 publications with MGEA5 and Skin
 Lymph Antibodies  >1 publications with MGEA5 and Lymph
 Lymph Node Antibodies  >1 publications with MGEA5 and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with MGEA5 and Embryonic Tissue
 Brain Antibodies  >1 publications with MGEA5 and Brain
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