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MLLT10 cdna clone

Scan QR to view Datasheet Catalog #    MBS1268511 MLLT10 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLLT10, cDNA Clone

 Also Known As   

MLLT10 cDNA Clone

 Product Gene Name   

MLLT10 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggtctcta gcgaccggcc cgtgtcactg gaggacgagg tctcccatag tatgaaggag atgattggag gctgttgcgt ttgctcagac gagagaggct gggccgagaa cccgctggtt tattgcgacg ggcacggctg cagcgtcgcg gtgcatcaag cttgctatgg cattgttcaa gtacccactg gaccgtggtt ttgcaggaaa tgtgaatctc aggagagagc agccagagtg gcagagtctc gctctgttgc ccaggctaaa gtgcagtggt gtgatctcag cccactgcaa cctctgctcc ccgggttcaa gcgattctcc tgcctcagcc tcccaaatgg tatgcaattc ctgttggtta gcctcatctg a
 OMIM    602409
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MLLT10 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MLLT10. It may not necessarily be applicable to this product.
 NCBI GI #    51593367
 NCBI GeneID    8028
 NCBI Accession #    BC080577 [Other Products]
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 UniProt Secondary Accession #    Q5JT37; Q5VX90; Q66K63; B1ANA8 [Other Products]
 UniProt Related Accession #    P55197 [Other Products]
 Molecular Weight    20,047 Da
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 NCBI Official Full Name    Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, mRNA
 NCBI Official Synonym Full Names    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
 NCBI Official Symbol    MLLT10 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein AF-10
 UniProt Protein Name    Protein AF-10
 UniProt Synonym Protein Names   
ALL1-fused gene from chromosome 10 protein
 Protein Family    Protein
 UniProt Gene Name    MLLT10 [Similar Products]
 UniProt Synonym Gene Names    AF10 [Similar Products]
 UniProt Entry Name    AF10_HUMAN
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 NCBI Summary for MLLT10    This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
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 UniProt Comments for MLLT10    MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: cytoplasm; nucleoplasm; nucleus; protein complex

Molecular Function: protein binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter

Disease: Leukemia, Acute Myeloid
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 Research Articles on MLLT10    1. The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with MLLT10 cdna cloneOrgans/Tissues associated with MLLT10 cdna clone
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >46 publications with MLLT10 and Leukemia, Myeloid, Acute
 Central Nervous System Diseases Antibodies  >1 publications with MLLT10 and Central Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with MLLT10 and Neoplasm Metastasis
 Brain Diseases Antibodies  >1 publications with MLLT10 and Brain Diseases
 Meningioma Antibodies  >1 publications with MLLT10 and Meningioma
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >16 publications with MLLT10 and Bone
 Blood Antibodies  >15 publications with MLLT10 and Blood
 Nerve Antibodies  >5 publications with MLLT10 and Nerve
 Testis Antibodies  >5 publications with MLLT10 and Testis
 Muscle Antibodies  >3 publications with MLLT10 and Muscle
 Brain Antibodies  >2 publications with MLLT10 and Brain
 Prostate Antibodies  >1 publications with MLLT10 and Prostate
 Thymus Antibodies  >1 publications with MLLT10 and Thymus
 Eye Antibodies  >1 publications with MLLT10 and Eye
 Placenta Antibodies  >1 publications with MLLT10 and Placenta
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