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MMP3 cdna clone

Scan QR to view Datasheet Catalog #    MBS1274190 MMP3 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MMP3, cDNA Clone

 Also Known As   

MMP3 cDNA Clone

 Product Gene Name   

MMP3 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    185250
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MMP3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MMP3. It may not necessarily be applicable to this product.
 NCBI GI #    46854934
 NCBI GeneID    4314
 NCBI Accession #    BC069676 [Other Products]
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 UniProt Secondary Accession #    Q3B7S0; Q6GRF8; B2R8B8 [Other Products]
 UniProt Related Accession #    P08254 [Other Products]
 Molecular Weight    53,977 Da
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 NCBI Official Full Name    Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase), mRNA
 NCBI Official Synonym Full Names    matrix metallopeptidase 3
 NCBI Official Symbol    MMP3 [Similar Products]
 NCBI Official Synonym Symbols   
SL-1; STMY; STR1; CHDS6; MMP-3; STMY1
[Similar Products]
 NCBI Protein Information    stromelysin-1
 UniProt Protein Name    Stromelysin-1
 UniProt Synonym Protein Names   
Matrix metalloproteinase-3; MMP-3; Transin-1
 Protein Family    Stromelysin
 UniProt Gene Name    MMP3 [Similar Products]
 UniProt Synonym Gene Names    STMY1; SL-1; MMP-3 [Similar Products]
 UniProt Entry Name    MMP3_HUMAN
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 NCBI Summary for MMP3    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MMP3    MMP3: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6). A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.17; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular region; extracellular space

Molecular Function: endopeptidase activity; metallopeptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: collagen catabolic process; extracellular matrix disassembly; positive regulation of protein oligomerization; proteolysis

Disease: Coronary Heart Disease, Susceptibility To, 6
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 Research Articles on MMP3    1. new evidence that promoter polymorphisms in MMP3 are functional and may affect gene transcription with possible effects on craniofacial development leading to NSCL/P.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MMP3 cdna cloneDiseases associated with MMP3 cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 EGFR Transactivation By Gastrin Pathway antibodies  EGFR Transactivation By Gastrin Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >127 publications with MMP3 and Neoplasms
 Inflammation Antibodies  >115 publications with MMP3 and Inflammation
 Cardiovascular Diseases Antibodies  >81 publications with MMP3 and Cardiovascular Diseases
 Necrosis Antibodies  >67 publications with MMP3 and Necrosis
 Nervous System Diseases Antibodies  >56 publications with MMP3 and Nervous System Diseases
 Heart Diseases Antibodies  >40 publications with MMP3 and Heart Diseases
 Atherosclerosis Antibodies  >36 publications with MMP3 and Atherosclerosis
 Neoplasm Invasiveness Antibodies  >31 publications with MMP3 and Neoplasm Invasiveness
 Coronary Artery Disease Antibodies  >30 publications with MMP3 and Coronary Artery Disease
 Lung Diseases Antibodies  >30 publications with MMP3 and Lung Diseases
Organs/Tissues associated with MMP3 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >80 publications with MMP3 and Bone
 Connective Tissue Antibodies  >43 publications with MMP3 and Connective Tissue
 Muscle Antibodies  >37 publications with MMP3 and Muscle
 Lung Antibodies  >34 publications with MMP3 and Lung
 Brain Antibodies  >34 publications with MMP3 and Brain
 Skin Antibodies  >29 publications with MMP3 and Skin
 Eye Antibodies  >15 publications with MMP3 and Eye
 Uterus Antibodies  >13 publications with MMP3 and Uterus
 Placenta Antibodies  >12 publications with MMP3 and Placenta
 Intestine Antibodies  >10 publications with MMP3 and Intestine
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