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MTA1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1274868 MTA1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTA1, cDNA Clone

★Popular Item★
 Also Known As   

MTA1 cDNA Clone

 Product Gene Name   

MTA1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgaagacca ggcaggcttt ctatctgcac acgacgaagc tgacgcggat cgcccggcgc ctgtgccgtg agatcctgcg cccgtggcac gctgcgcggc acccctacct gcccatcaac agcgcggcca tcaaggccga gtgcacggcg cggctgcccg aagcctccca gagcccgctg gtgctgaagc aggcggtacg caagccgctg gaagccgtgc ttcggtatct tgagacccac ccccgccccc ccaagcctga ccccgtgaaa agcgtgtcca gcgtgctcag cagcctgacg cccgccaagg tggcccccgt catcaacaac ggctccccca ccatcctggg caagcgcagc tacgagcagc acaacggggt ggacggcaac atgaagaagc gcctcttgat gcccagtagg ggcacttacc tgggtctggc aaaccacgga cagaccaggc acatgggacc aagccggaac ctcctgctca acgggaagtc ctaccccacc aaagtgcgcc tgatccgggg gggctccctg cccccagtca agcggcggcg gatgaactgg atcgacgccc cggatgacgt gttctacatg gccacagagg agaccaggaa gatccgcaag ctgctctcat cctcggaaac caagcgtgct gcccgccggc cctacaagcc catcgccctg cgccagagcc aggccctgcc gccgcggcca ccgccacctg cgcccgtcaa cgacgagccc atcgtcatcg aggactag
 OMIM    603526
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MTA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MTA1. It may not necessarily be applicable to this product.
 NCBI GI #    13544097
 NCBI GeneID    9112
 NCBI Accession #    BC006177 [Other Products]
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 UniProt Secondary Accession #    Q86SW2; Q8NFI8; Q96GI8; A5PLK4 [Other Products]
 UniProt Related Accession #    Q13330 [Other Products]
 Molecular Weight    79,192 Da
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 NCBI Official Full Name    Homo sapiens metastasis associated 1, mRNA
 NCBI Official Synonym Full Names    metastasis associated 1
 NCBI Official Symbol    MTA1 [Similar Products]
 NCBI Protein Information    metastasis-associated protein MTA1
 UniProt Protein Name    Metastasis-associated protein MTA1
 Protein Family    Mating type protein
 UniProt Gene Name    MTA1 [Similar Products]
 UniProt Entry Name    MTA1_HUMAN
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 NCBI Summary for MTA1    This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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 UniProt Comments for MTA1    MTA1: metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: cytoplasm; intracellular membrane-bound organelle; microtubule; nuclear envelope; nucleoplasm; nucleus

Molecular Function: histone deacetylase activity; protein binding; transcription coactivator activity; transcription corepressor activity

Biological Process: circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; locomotor rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation; regulation of gene expression, epigenetic; regulation of inflammatory response; response to ionizing radiation; response to lipopolysaccharide; signal transduction
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 Research Articles on MTA1    1. Inhibition of MTA1 by ERalpha contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MTA1 cdna cloneDiseases associated with MTA1 cdna clone
 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >103 publications with MTA1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >53 publications with MTA1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >19 publications with MTA1 and Liver Neoplasms
 Liver Diseases Antibodies  >18 publications with MTA1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >15 publications with MTA1 and Carcinoma, Hepatocellular
 Ovarian Neoplasms Antibodies  >13 publications with MTA1 and Ovarian Neoplasms
 Cell Transformation, Neoplastic Antibodies  >9 publications with MTA1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >9 publications with MTA1 and Inflammation
 Hepatitis Antibodies  >7 publications with MTA1 and Hepatitis
 Pancreatic Neoplasms Antibodies  >7 publications with MTA1 and Pancreatic Neoplasms
Organs/Tissues associated with MTA1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Lymph Antibodies  >34 publications with MTA1 and Lymph
 Lymph Node Antibodies  >34 publications with MTA1 and Lymph Node
 Liver Antibodies  >23 publications with MTA1 and Liver
 Lung Antibodies  >19 publications with MTA1 and Lung
 Blood Antibodies  >13 publications with MTA1 and Blood
 Prostate Antibodies  >10 publications with MTA1 and Prostate
 Mammary Gland Antibodies  >10 publications with MTA1 and Mammary Gland
 Testis Antibodies  >10 publications with MTA1 and Testis
 Brain Antibodies  >10 publications with MTA1 and Brain
 Embryonic Tissue Antibodies  >7 publications with MTA1 and Embryonic Tissue
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