BC006177
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,192 Da
NCBI Official Full Name
Homo sapiens metastasis associated 1, mRNA
NCBI Official Synonym Full Names
metastasis associated 1
NCBI Protein Information
metastasis-associated protein MTA1
UniProt Protein Name
Metastasis-associated protein MTA1
UniProt Entry Name
MTA1_HUMAN
NCBI Summary for MTA1
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for MTA1
MTA1: metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 14q32.3
Cellular Component: cytoplasm; intracellular membrane-bound organelle; microtubule; nuclear envelope; nucleoplasm; nucleus
Molecular Function: histone deacetylase activity; protein binding; transcription coactivator activity; transcription corepressor activity
Biological Process: circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; locomotor rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation; regulation of gene expression, epigenetic; regulation of inflammatory response; response to ionizing radiation; response to lipopolysaccharide; signal transduction
Research Articles on MTA1
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Pathways associated with MTA1 cdna clone
Diseases associated with MTA1 cdna clone
Organs/Tissues associated with MTA1 cdna clone
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