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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

MTAP cdna clone

Scan QR to view Datasheet Catalog #    MBS1275903 MTAP cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MTAP, cDNA Clone

 Also Known As   

MTAP cDNA Clone

 Product Gene Name   

MTAP cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcctctg gcaccaccac caccgccgtg aagattggaa taattggtgg aacaggcctg gatgatccag aaattttaga aggaagaact gaaaaatatg tggatactcc atttggcaag ccatctgatg ccttaatttt ggggaagata aaaaatgttg attgcatcct ccttgcaagg catggaaggc agcacaccat catgccttca aaggtcaact accaggcgaa catctgggct ttgaaggaag agggctgtac acatgtcata gtgaccacag cttgtggctc cttgagggag gagattcagc ccggcgatat tgtcattatt gatcagttca ttgacagcca tgtaagacgt gcctgcttcc ccttcacctt ccatcatgat tgtttccaga gacctcccca gaagccaagc agaagccact gtgtttcctg tgcaacctgc agaaccatga gctaa
 OMIM    112250
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MTAP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MTAP. It may not necessarily be applicable to this product.
 NCBI GI #    17391371
 NCBI GeneID    4507
 NCBI Accession #    BC018625 [Other Products]
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 UniProt Secondary Accession #    Q5T3P3; Q9H010; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0 [Other Products]
 UniProt Related Accession #    Q13126 [Other Products]
 Molecular Weight    26,278 Da
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 NCBI Official Full Name    Homo sapiens methylthioadenosine phosphorylase, mRNA
 NCBI Official Synonym Full Names    methylthioadenosine phosphorylase
 NCBI Official Symbol    MTAP [Similar Products]
 NCBI Official Synonym Symbols   
BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249
[Similar Products]
 NCBI Protein Information    S-methyl-5'-thioadenosine phosphorylase
 UniProt Protein Name    S-methyl-5'-thioadenosine phosphorylase
 UniProt Synonym Protein Names   
5'-methylthioadenosine phosphorylase
 UniProt Gene Name    MTAP [Similar Products]
 UniProt Synonym Gene Names    MTA phosphorylase; MTAP; MTAPase [Similar Products]
 UniProt Entry Name    MTAP_HUMAN
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 NCBI Summary for MTAP    This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MTAP    MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Phosphorylase; Transferase

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; cytosol

Molecular Function: phosphorylase activity; protein binding; S-methyl-5-thioadenosine phosphorylase activity

Biological Process: methionine salvage; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine salvage
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 Research Articles on MTAP    1. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MTAP cdna cloneDiseases associated with MTAP cdna clone
 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 Methionine Salvage Pathway antibodies  Methionine Salvage Pathway Diagram
 S-methyl-5'-thioadenosine Degradation II Pathway antibodies  S-methyl-5'-thioadenosine Degradation II Pathway Diagram
 S-methyl-5'-thioadenosine Degradation II Pathway antibodies  S-methyl-5'-thioadenosine Degradation II Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >137 publications with MTAP and Neoplasms
 Carcinoma Antibodies  >34 publications with MTAP and Carcinoma
 Melanoma Antibodies  >23 publications with MTAP and Melanoma
 Adenocarcinoma Antibodies  >16 publications with MTAP and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >9 publications with MTAP and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >8 publications with MTAP and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >7 publications with MTAP and Pancreatic Neoplasms
 Intestinal Neoplasms Antibodies  >7 publications with MTAP and Intestinal Neoplasms
 Neoplasms, Experimental Antibodies  >7 publications with MTAP and Neoplasms, Experimental
 Arteriosclerosis Antibodies  >6 publications with MTAP and Arteriosclerosis
Organs/Tissues associated with MTAP cdna clone
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >18 publications with MTAP and Lung
 Blood Antibodies  >17 publications with MTAP and Blood
 Skin Antibodies  >15 publications with MTAP and Skin
 Brain Antibodies  >14 publications with MTAP and Brain
 Liver Antibodies  >6 publications with MTAP and Liver
 Lymph Node Antibodies  >5 publications with MTAP and Lymph Node
 Intestine Antibodies  >4 publications with MTAP and Intestine
 Embryonic Tissue Antibodies  >4 publications with MTAP and Embryonic Tissue
 Bone Marrow Antibodies  >3 publications with MTAP and Bone Marrow
 Heart Antibodies  >3 publications with MTAP and Heart
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