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MVK cdna clone

Scan QR to view Datasheet Catalog #    MBS1266849 MVK cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MVK, cDNA Clone

★Popular Item★
 Also Known As   

MVK cDNA Clone

 Product Gene Name   

MVK cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgttgtcag aagtcctact ggtgtctgct ccggggaaag tcatccttca tggagaacat gccgtggtac atggcaaggt agcactggct gtatccttga acttgagaac attcctccgg cttcaacccc acagcaatgg gaaagtggac ctcagcttac ccaacattgg tatcaagcgg gcctgggatg tggccaggct tcagtcactg gacacaagct ttctggagca aggtgatgtc acaacaccca cctcagagca agtggagaag ctaaaggagg ttgcaggctt gcctgacgac tgtgctgtca ccgagcgcct ggctgtgctg gcctttcttt acttatacct gtccatctgc cggaagcaga gggccctgcc gagcctggat atcgtagtgt ggtcggagct gccccccggg gcgggcttgg gctccagcgc cgcctactcg gtgtgtctgg cagcagccct cctgactgtg tgcgaggaga tcccaaaccc gctgaaggac ggggattgcg tcaacaggtg gaccaaggag gatttggagc taattaacaa gtgggccttc caaggggaga gaatgattca cgggaacccc tccggagtgg acaatgctgt cagcacctgg ggaggagccc tccgatacca tcaagggaag atttcatcct taaagaggtc gccagctctc cagatcctgc tgaccaacac caaagtccct cgcaatacca gggcccttgt ggctggcgtc agaaacaggc tgctcaagtt cccagagatc gtggcccccc tcctgacctc aatagatgcc atctccctgg agtgtgagcg cgtgctggga gagatggggg aagccccagc cccggagcag tacctcgtgc tggaagagct cattgacatg aaccagcacc atctgaatgc cctcggcgtg ggccacgcct ctctggacca gctctgccag gtgaccaggg cccgcggact tcacagcaag ctgactggcg caggcggtgg tggctgtggc atcacactcc tcaagccagg gctggagcag ccagaagtgg aggccacgaa gcaggccctg accagctgtg gctttgactg cttggaaacc agcatcggtg cccccggcgt ctccatccac tcagccacct ccctggacag ccgagtccag caagccctgg atggcctctg a
 OMIM    175900
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MVK cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MVK. It may not necessarily be applicable to this product.
 NCBI GI #    16359370
 NCBI GeneID    4598
 NCBI Accession #    BC016140 [Other Products]
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 UniProt Related Accession #    Q03426 [Other Products]
 Molecular Weight    42,451 Da
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 NCBI Official Full Name    Homo sapiens mevalonate kinase, mRNA
 NCBI Official Synonym Full Names    mevalonate kinase
 NCBI Official Symbol    MVK [Similar Products]
 NCBI Official Synonym Symbols   
MK; LRBP; MVLK; POROK3
[Similar Products]
 NCBI Protein Information    mevalonate kinase
 UniProt Protein Name    Mevalonate kinase
 Protein Family    Mevalonate kinase
 UniProt Gene Name    MVK [Similar Products]
 UniProt Synonym Gene Names    MK [Similar Products]
 UniProt Entry Name    KIME_HUMAN
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 NCBI Summary for MVK    This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for MVK    MVK: May be a regulatory site in cholesterol biosynthetic pathway. Defects in MVK are the cause of mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.7.1.36; RNA-binding; Kinase, other; Translation

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytosol; peroxisome

Molecular Function: identical protein binding; mevalonate kinase activity; protein binding

Biological Process: cholesterol biosynthetic process; isoprenoid biosynthetic process; negative regulation of inflammatory response

Disease: Hyper-igd Syndrome; Mevalonic Aciduria; Porokeratosis 3, Disseminated Superficial Actinic Type
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 Research Articles on MVK    1. Wild-type MK and the variant V261A, which is associated with HIDS, were recombinantly expressed in Escherichia coli. Enzyme activity was determined by formation of MVAP over time
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MVK cdna cloneDiseases associated with MVK cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway antibodies  Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway Diagram
 Disease Name  Pubmed Publications
 Fever Antibodies  >50 publications with MVK and Fever
 Mevalonate Kinase Deficiency Antibodies  >39 publications with MVK and Mevalonate Kinase Deficiency
 Necrosis Antibodies  >25 publications with MVK and Necrosis
 Nervous System Diseases Antibodies  >22 publications with MVK and Nervous System Diseases
 Pain Antibodies  >12 publications with MVK and Pain
 Inflammation Antibodies  >11 publications with MVK and Inflammation
 Arthralgia Antibodies  >9 publications with MVK and Arthralgia
 Drug Toxicity Antibodies  >9 publications with MVK and Drug Toxicity
 Disease Models, Animal Antibodies  >6 publications with MVK and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >5 publications with MVK and Cell Transformation, Neoplastic
Organs/Tissues associated with MVK cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with MVK and Blood
 Skin Antibodies  >17 publications with MVK and Skin
 Ovary Antibodies  >11 publications with MVK and Ovary
 Liver Antibodies  >8 publications with MVK and Liver
 Kidney Antibodies  >6 publications with MVK and Kidney
 Bone Antibodies  >5 publications with MVK and Bone
 Brain Antibodies  >5 publications with MVK and Brain
 Heart Antibodies  >3 publications with MVK and Heart
 Spleen Antibodies  >3 publications with MVK and Spleen
 Embryonic Tissue Antibodies  >2 publications with MVK and Embryonic Tissue
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