BC038840
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,354 Da
NCBI Official Full Name
Homo sapiens N-acetylated alpha-linked acidic dipeptidase 2, mRNA
NCBI Official Synonym Full Names
N-acetylated alpha-linked acidic dipeptidase 2
NCBI Official Synonym Symbols
GCPIII; GPCIII; NAADALASE2; NAALADASE2 [Similar Products]
NCBI Protein Information
N-acetylated-alpha-linked acidic dipeptidase 2
UniProt Protein Name
N-acetylated-alpha-linked acidic dipeptidase 2
UniProt Synonym Protein Names
Glutamate carboxypeptidase III; GCPIII; N-acetylated-alpha-linked acidic dipeptidase II; NAALADase II
UniProt Synonym Gene Names
UniProt Entry Name
NALD2_HUMAN
NCBI Summary for NAALAD2
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for NAALAD2
NAALAD2: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N- acetylaspartylglutamate. Belongs to the peptidase M28 family. M28B subfamily.
Protein type: Membrane protein, integral; EC 3.4.17.21; Protease
Chromosomal Location of Human Ortholog: 11q14.3-q21
Cellular Component: plasma membrane
Molecular Function: dipeptidase activity
Biological Process: amino acid biosynthetic process
Research Articles on NAALAD2
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Organs/Tissues associated with NAALAD2 cdna clone
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