BC019315
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,308 Da
NCBI Official Full Name
Homo sapiens N-acetylneuraminic acid synthase, mRNA
NCBI Official Synonym Full Names
N-acetylneuraminate synthase
NCBI Protein Information
sialic acid synthase
UniProt Protein Name
Sialic acid synthase
UniProt Synonym Protein Names
N-acetylneuraminate synthase (EC:2.5.1.56); N-acetylneuraminate-9-phosphate synthase (EC:2.5.1.57); N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase
UniProt Synonym Gene Names
UniProt Entry Name
SIAS_HUMAN
NCBI Summary for NANS
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
UniProt Comments for NANS
NANS: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Protein type: Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.5.1.56; EC 2.5.1.57
Chromosomal Location of Human Ortholog: 9p24.1-p23
Cellular Component: cytosol
Molecular Function: N-acylneuraminate-9-phosphate synthase activity
Disease: Spondyloepimetaphyseal Dysplasia, Genevieve Type
Research Articles on NANS
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Pathways associated with NANS cdna clone
Diseases associated with NANS cdna clone
Organs/Tissues associated with NANS cdna clone
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