BC032466
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,099 Da
NCBI Official Full Name
Homo sapiens nicotinate phosphoribosyltransferase domain containing 1, mRNA
NCBI Official Synonym Full Names
nicotinate phosphoribosyltransferase
NCBI Protein Information
nicotinate phosphoribosyltransferase
UniProt Protein Name
Nicotinate phosphoribosyltransferase
UniProt Synonym Protein Names
FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
PNCB_HUMAN
NCBI Summary for NAPRT1
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
UniProt Comments for NAPRT1
NAPRT1: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. Belongs to the NAPRTase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.4.21; Transferase
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleus
Molecular Function: nicotinate phosphoribosyltransferase activity; protein binding
Biological Process: nicotinamide metabolic process; response to oxidative stress
Research Articles on NAPRT1
Precautions
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Pathways associated with NAPRT1 cdna clone
Diseases associated with NAPRT1 cdna clone
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