BC012037
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,169 Da
NCBI Official Full Name
Homo sapiens neuroblastoma, suppression of tumorigenicity 1, mRNA
NCBI Official Synonym Full Names
neuroblastoma 1, DAN family BMP antagonist
NCBI Protein Information
neuroblastoma suppressor of tumorigenicity 1
UniProt Protein Name
Neuroblastoma suppressor of tumorigenicity 1
UniProt Synonym Protein Names
DAN domain family member 1; Protein N03; Zinc finger protein DAN
UniProt Synonym Gene Names
UniProt Entry Name
NBL1_HUMAN
NCBI Summary for NBL1
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
UniProt Comments for NBL1
NBL1 iso2: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: extracellular space
Molecular Function: morphogen activity; protein binding; protein homodimerization activity
Biological Process: determination of dorsal identity; negative regulation of BMP signaling pathway; nervous system development; neurite morphogenesis; positive regulation of neuron differentiation
Research Articles on NBL1
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Organs/Tissues associated with NBL1 cdna clone
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