BC001562
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,649 Da
NCBI Official Full Name
Homo sapiens nuclear receptor coactivator 4, mRNA
NCBI Official Synonym Full Names
nuclear receptor coactivator 4
NCBI Protein Information
nuclear receptor coactivator 4
UniProt Protein Name
Nuclear receptor coactivator 4
UniProt Synonym Protein Names
Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1
UniProt Synonym Gene Names
ARA70; ELE1; RFG; NCoA-4; 70 kDa AR-activator; 70 kDa androgen receptor coactivator [Similar Products]
UniProt Entry Name
NCOA4_HUMAN
NCBI Summary for NCOA4
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
UniProt Comments for NCOA4
NCOA4: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: nucleus
Biological Process: male gonad development
Disease: Thyroid Carcinoma, Papillary
Research Articles on NCOA4
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Pathways associated with NCOA4 cdna clone
Diseases associated with NCOA4 cdna clone
Organs/Tissues associated with NCOA4 cdna clone
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