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NDE1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270776 NDE1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NDE1, cDNA Clone

 Also Known As   

NDE1 cDNA Clone

 Product Gene Name   

NDE1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggaggact ccggaaagac tttcagctcc gaggaggaag aagctaacta ttggaaagat ctggcgatga cctacaaaca gagggcagaa aatacgcaag aggaactccg agaattccag gagggaagcc gagaatatga agctgaattg gagacgcagc tgcaacaaat tgaaaccagg aacagagacc tcctgtccga aaataaccgc cttcgcatgg agctggaaac catcaaggag aagtttgaag tgcagcactc tgaaggctac cggcagatct cagccttgga ggatgacctc gcgcagacca aagccattaa agaccaattg cagaaataca tcagagagct ggagcaagca aatgacgacc tggaaagagc caagcgcgcc acgatcatgt ctctcgaaga ctttgagcag cgcttgaatc aggccatcga aagaaatgcc ttcctggaaa gtgaacttga tgaaaaagag aatctcctgg aatctgttca gagactgaag gatgaagcca gagatttgcg gcaggaactg gccgtgcagc agaagcagga gaaacccagg acccccatgc ccagctcagt ggaagctgag aggacagaca cagctgtgca ggccacgggc tccgtgccgt ccacgcccat tgctcaccga ggacccagct caagtttaaa cacacctggg agcttcagac gtggcctgga cgactccacc ggggggaccc ccctcacacc tgcggcccgg atatcagccc tcaacattgt gggagaccta ctgcggaaag tcggggcact ggagtccaaa ctcgcttcct gccggaacct cgtgtacgat cagtccccaa accgaacagg tggcccagcc tctgggcgga gcagcaagaa cagagatggc ggggagagac ggccaagcag caccagcgtg cctttgggtg ataaggggtt ggacacgagt tgccgctggt tgtccaaatc aacaaccagg tcgtccagct cctgctga
 OMIM    605013
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NDE1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NDE1. It may not necessarily be applicable to this product.
 NCBI GI #    33876196
 NCBI GeneID    54820
 NCBI Accession #    BC001421 [Other Products]
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 UniProt Secondary Accession #    Q49AQ2 [Other Products]
 UniProt Related Accession #    Q9NXR1 [Other Products]
 Molecular Weight    37,721 Da
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 NCBI Official Full Name    Homo sapiens nudE nuclear distribution gene E homolog 1 (A. nidulans), mRNA
 NCBI Official Synonym Full Names    nudE neurodevelopment protein 1
 NCBI Official Symbol    NDE1 [Similar Products]
 NCBI Official Synonym Symbols   
NDE; LIS4; MHAC; NUDE; NUDE1; HOM-TES-87
[Similar Products]
 NCBI Protein Information    nuclear distribution protein nudE homolog 1
 UniProt Protein Name    Nuclear distribution protein nudE homolog 1
 Protein Family    Nuclear distribution protein
 UniProt Gene Name    NDE1 [Similar Products]
 UniProt Synonym Gene Names    NUDE; NudE [Similar Products]
 UniProt Entry Name    NDE1_HUMAN
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 NCBI Summary for NDE1    This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
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 UniProt Comments for NDE1    NUDE1: a microtubule-associated protein required for centrosome duplication, and the formation and function of the mitotic spindle. Associated with the centrosome, kinetochore, and spindle. Specifically phosphorylated during M phase, inducing its association with mitotic spindles. Appears to participate in dynein-mediated transport of kinetochore proteins to spindle poles along microtubules. Interacts with gamma tubulin, dynactin, CEP110, dynein,TCP1. PAFAH1B1, PCM-1 and PCNT. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase, and at the cleavage furrow during cytokinesis.Two alternatively spliced human isoforms have been described.

Protein type: Cytoskeletal; Microtubule-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p13.11

Cellular Component: centrosome; cytosol; kinesin complex; kinetochore; membrane; spindle pole centrosome

Molecular Function: microtubule binding; protein binding

Biological Process: cell migration; centrosome duplication; centrosome localization; cerebral cortex development; chromosome segregation; establishment of chromosome localization; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; microtubule nucleation; mitotic centrosome separation; sister chromatid cohesion; vesicle transport along microtubule

Disease: Lissencephaly 4; Microhydranencephaly
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 Research Articles on NDE1    1. Interaction between NDE1 and high birth weight was associated with increased susceptibility to schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NDE1 cdna cloneDiseases associated with NDE1 cdna clone
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Malformations Antibodies  >6 publications with NDE1 and Nervous System Malformations
 Neoplasms Antibodies  >5 publications with NDE1 and Neoplasms
 Disease Models, Animal Antibodies  >4 publications with NDE1 and Disease Models, Animal
 Death Antibodies  >4 publications with NDE1 and Death
 Carcinoma Antibodies  >1 publications with NDE1 and Carcinoma
 Learning Disorders Antibodies  >1 publications with NDE1 and Learning Disorders
 Kidney Diseases Antibodies  >1 publications with NDE1 and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with NDE1 and Liver Diseases
 Breast Neoplasms Antibodies  >1 publications with NDE1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >1 publications with NDE1 and Liver Neoplasms
Organs/Tissues associated with NDE1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with NDE1 and Brain
 Nerve Antibodies  >16 publications with NDE1 and Nerve
 Embryonic Tissue Antibodies  >1 publications with NDE1 and Embryonic Tissue
 Liver Antibodies  >1 publications with NDE1 and Liver
 Heart Antibodies  >1 publications with NDE1 and Heart
 Kidney Antibodies  >1 publications with NDE1 and Kidney
 Eye Antibodies  >1 publications with NDE1 and Eye
 Prostate Antibodies  >1 publications with NDE1 and Prostate
 Skin Antibodies  >1 publications with NDE1 and Skin
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