BC032555
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,000 Da
NCBI Official Full Name
Homo sapiens neuroligin 1, mRNA
NCBI Official Synonym Full Names
neuroligin 1
NCBI Official Synonym Symbols
NCBI Protein Information
neuroligin-1
UniProt Protein Name
Neuroligin-1
UniProt Synonym Gene Names
UniProt Entry Name
NLGN1_HUMAN
NCBI Summary for NLGN1
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
UniProt Comments for NLGN1
NLGN1: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component: cell surface; dendrite; dendritic spine; extracellular space; filopodium tip; Golgi apparatus; integral to plasma membrane; plasma membrane; postsynaptic density; synapse
Molecular Function: cell adhesion molecule binding; neurexin binding; PDZ domain binding; protein dimerization activity; receptor activity
Biological Process: calcium-dependent cell-cell adhesion; cytoskeletal matrix organization at active zone; establishment of protein localization; heterophilic cell adhesion; nervous system development; neurite development; neuron adhesion; positive regulation of filopodium formation; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein homooligomerization; protein targeting; regulation of neuron differentiation; synaptic vesicle targeting; synaptogenesis
Research Articles on NLGN1
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Pathways associated with NLGN1 cdna clone
Diseases associated with NLGN1 cdna clone
Organs/Tissues associated with NLGN1 cdna clone
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