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NME1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1268121 NME1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NME1, cDNA Clone

★Popular Item★
 Also Known As   

NME1 cDNA Clone

 Product Gene Name   

NME1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggccaact gtgagcgtac cttcattgcg atcaaaccag atggggtcca gcggggtctt gtgggagaga ttatcaagcg ttttgagcag aaaggattcc gccttgttgg tctgaaattc atgcaagctt ccgaagatct tctcaaggaa cactacgttg acctgaagga ccgtccattc tttgccggcc tggtgaaata catgcactca gggccggtag ttgccatggt ctgggagggg ctgaatgtgg tgaagacggg ccgagtcatg ctcggggaga ccaaccctgc agactccaag cctgggacca tccgtggaga cttctgcata caagttggca ggaacattat acatggcagt gattctgtgg agagtgcaga gaaggagatc ggcttgtggt ttcaccctga ggaactggta gattacacga gctgtgctca gaactggatc tatgaatga
 OMIM    156490
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NME1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NME1. It may not necessarily be applicable to this product.
 NCBI GI #    33988469
 NCBI GeneID    4830
 NCBI Accession #    BC000293 [Other Products]
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 UniProt Secondary Accession #    Q6FGK3; Q86XQ2; Q9UDJ6 [Other Products]
 UniProt Related Accession #    P15531 [Other Products]
 Molecular Weight    30,137 Da
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 NCBI Official Full Name    Homo sapiens non-metastatic cells 1, protein (NM23A) expressed in, mRNA
 NCBI Official Synonym Full Names    NME/NM23 nucleoside diphosphate kinase 1
 NCBI Official Symbol    NME1 [Similar Products]
 NCBI Official Synonym Symbols   
NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1
[Similar Products]
 NCBI Protein Information    nucleoside diphosphate kinase A
 UniProt Protein Name    Nucleoside diphosphate kinase A
 UniProt Synonym Protein Names   
Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated protein
 Protein Family    Nucleoside diphosphate kinase
 UniProt Gene Name    NME1 [Similar Products]
 UniProt Synonym Gene Names    NDPKA; NM23; NDK A; NDP kinase A; GAAD [Similar Products]
 UniProt Entry Name    NDKA_HUMAN
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 NCBI Summary for NME1    This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NME1    NME1: an enzyme with multiple activities including histidine protein kinase, nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase and 3'-5' exonuclease activities. Plays a major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Involved in cell proliferation, differentiation and development, G protein-coupled receptor endocytosis, cytotoxic T cell and NK cell-mediated cell death, and gene expression. Required for neural development including neural patterning and cell fate determination. During granzyme A (GZMA)-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Three alternatively spliced human proteins have been reported.

Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Kinase, nucleoside diphosphate; Protein kinase, histidine; EC 2.7.4.6; Tumor suppressor; Kinase, other; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: cytoplasm; cytosol; membrane; nucleus

Molecular Function: ATP binding; deoxyribonuclease activity; GTP binding; identical protein binding; magnesium ion binding; nucleoside diphosphate kinase activity; protein binding; ribosomal small subunit binding

Biological Process: negative regulation of cell proliferation; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of DNA binding; positive regulation of epithelial cell proliferation; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of apoptosis

Disease: Neuroblastoma, Susceptibility To
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 Research Articles on NME1    1. NM23 expression is reduced in CRC tissues and low NM23 levels tightly correlate with higher Dukes stages, poorer differentiation grade, and positive lymph node metastases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NME1 cdna cloneDiseases associated with NME1 cdna clone
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >776 publications with NME1 and Neoplasms
 Carcinoma Antibodies  >441 publications with NME1 and Carcinoma
 Neoplasm Metastasis Antibodies  >422 publications with NME1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >167 publications with NME1 and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >99 publications with NME1 and Neoplasm Invasiveness
 Carcinoma, Squamous Cell Antibodies  >90 publications with NME1 and Carcinoma, Squamous Cell
 Colorectal Neoplasms Antibodies  >89 publications with NME1 and Colorectal Neoplasms
 Lung Neoplasms Antibodies  >86 publications with NME1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >72 publications with NME1 and Liver Neoplasms
 Liver Diseases Antibodies  >60 publications with NME1 and Liver Diseases
Organs/Tissues associated with NME1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Lymph Antibodies  >190 publications with NME1 and Lymph
 Lymph Node Antibodies  >189 publications with NME1 and Lymph Node
 Lung Antibodies  >95 publications with NME1 and Lung
 Blood Antibodies  >88 publications with NME1 and Blood
 Liver Antibodies  >79 publications with NME1 and Liver
 Stomach Antibodies  >47 publications with NME1 and Stomach
 Vascular Antibodies  >44 publications with NME1 and Vascular
 Bone Antibodies  >27 publications with NME1 and Bone
 Brain Antibodies  >26 publications with NME1 and Brain
 Kidney Antibodies  >25 publications with NME1 and Kidney
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