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NMNAT1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1273835 NMNAT1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NMNAT1, cDNA Clone

 Also Known As   

NMNAT1 cDNA Clone

 Product Gene Name   

NMNAT1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggaaaatt ccgagaagac tgaagtggtt ctccttgctt gtggttcatt caatcccatc accaacatgc acctcaggtt gtttgagctg gccaaggact acatgaatgg aacaggaagg tacacagttg tcaaaggcat catctctcct gttggtgatg cctacaagaa gaaaggactc attcctgcct atcaccgggt catcatggca gaacttgcta ccaagaattc taaatgggtg gaagttgata catgggaaag tcttcagaag gagtggaaag agactctgaa ggtgctaaga caccatcaag agaaattgga ggctagtgac tgtgatcacc agcagaactc acctactcta gaaaggcctg gaaggaagag gaagtggact gaaacacaag attctagtca aaagaaatcc ctagagccaa aaacaaaagc tgtgccaaag gtcaagctgc tgtgtggggc agatttattg gagtcctttg ctgttcccaa tttgtggaag agtgaagaca tcacccaaat cgtggccaac tatgggctca tatgtgttac tcgggctgga aatgatgctc agaagtttat ctatgaatcg gatgtgctgt ggaaacaccg gagcaacatt cacgtggtga atgaatggat cgctaatgac atctcatcca caaaaatccg gagagccctc agaaggggcc agagcattcg ctacttggta ccagatcttg tccaagaata cattgaaaag cataatttgt acagctctga gagtgaagac aggaatgctg gggtcatcct ggcccctttg cagagaaaca ctgcagaagc taagacatag
 OMIM    608553
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NMNAT1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NMNAT1. It may not necessarily be applicable to this product.
 NCBI GI #    15928949
 NCBI GeneID    64802
 NCBI Accession #    BC014943 [Other Products]
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 UniProt Secondary Accession #    Q8TAE9; Q9H247; Q9H6B6; B1AN63 [Other Products]
 UniProt Related Accession #    Q9HAN9 [Other Products]
 Molecular Weight    31,932 Da
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 NCBI Official Full Name    Homo sapiens nicotinamide nucleotide adenylyltransferase 1, mRNA
 NCBI Official Synonym Full Names    nicotinamide nucleotide adenylyltransferase 1
 NCBI Official Symbol    NMNAT1 [Similar Products]
 NCBI Official Synonym Symbols   
LCA9; NMNAT; PNAT1
[Similar Products]
 NCBI Protein Information    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
 UniProt Protein Name    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
 UniProt Synonym Protein Names   
Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1
 UniProt Gene Name    NMNAT1 [Similar Products]
 UniProt Synonym Gene Names    NMNAT; NMN/NaMN adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1 [Similar Products]
 UniProt Entry Name    NMNA1_HUMAN
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 NCBI Summary for NMNAT1    This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
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 UniProt Comments for NMNAT1    NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.1; EC 2.7.7.18; Transferase

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function: identical protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; protein binding

Biological Process: NAD biosynthetic process; NAD metabolic process

Disease: Leber Congenital Amaurosis 9
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 Research Articles on NMNAT1    1. Hidden Genetic Variation in LCA9-Associated Congenital Blindness Explained by 5'UTR Mutations and Copy-Number Variations of NMNAT1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NMNAT1 cdna cloneDiseases associated with NMNAT1 cdna clone
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis III Pathway antibodies  NAD Biosynthesis III Pathway Diagram
 NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  NAD Biosynthesis From 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 NAD Salvage Pathway II antibodies  NAD Salvage Pathway II Diagram
 NAD Salvage Pathway III antibodies  NAD Salvage Pathway III Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >16 publications with NMNAT1 and Neurodegenerative Diseases
 Leber Congenital Amaurosis Antibodies  >7 publications with NMNAT1 and Leber Congenital Amaurosis
 Disease Models, Animal Antibodies  >6 publications with NMNAT1 and Disease Models, Animal
 Retinal Degeneration Antibodies  >4 publications with NMNAT1 and Retinal Degeneration
 Drug Toxicity Antibodies  >2 publications with NMNAT1 and Drug Toxicity
 Necrosis Antibodies  >2 publications with NMNAT1 and Necrosis
 Optic Atrophy Antibodies  >2 publications with NMNAT1 and Optic Atrophy
 Macular Degeneration Antibodies  >2 publications with NMNAT1 and Macular Degeneration
 Brain Injuries Antibodies  >1 publications with NMNAT1 and Brain Injuries
 Inflammation Antibodies  >1 publications with NMNAT1 and Inflammation
Organs/Tissues associated with NMNAT1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with NMNAT1 and Brain
 Eye Antibodies  >5 publications with NMNAT1 and Eye
 Lung Antibodies  >2 publications with NMNAT1 and Lung
 Kidney Antibodies  >2 publications with NMNAT1 and Kidney
 Muscle Antibodies  >2 publications with NMNAT1 and Muscle
 Embryonic Tissue Antibodies  >2 publications with NMNAT1 and Embryonic Tissue
 Blood Antibodies  >1 publications with NMNAT1 and Blood
 Heart Antibodies  >1 publications with NMNAT1 and Heart
 Prostate Antibodies  >1 publications with NMNAT1 and Prostate
 Spleen Antibodies  >1 publications with NMNAT1 and Spleen
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