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NONO cdna clone

Scan QR to view Datasheet Catalog #    MBS1277337 NONO cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NONO, cDNA Clone

 Also Known As   


 Product Gene Name   

NONO cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgccactcc gtggaaagca gctgcgtgtg cgctttgcct gccatagtgc atcccttaca gttcgaaacc ttcctcagta tgtgtccaac gaactgctgg aagaagcctt ttctgtgttt ggccaggtag agagggctgt agtcattgtg gatgatcgag gaaggccctc aggaaaaggc attgttgagt tctcagggaa gccagctgct cggaaagctc tggacagatg cagtgaaggc tccttcctgc taaccacatt tcctcgtcct gtgactgtgg agcccatgga ccagttagat gatgaagagg gacttccaga gaagctggtt ataaaaaacc agcaatttca caaggaacga gagcagccac ccagatttgc acagcctggc tcctttgagt atgaatatgc catgcgctgg aaggcactca ttgagatgga gaagcagcag caggaccaag tggaccgcaa catcaaggag gctcgtgaga agctggagat ggagatggaa gctgcacgcc atgagcacca ggtcatgcta atgagacagg atttgatgag gcgccaagaa gaacttcgga ggatggaaga gctgcacaac caagaggtgc aaaaacgaaa gcaactggag ctcaggcagg aggaagagcg caggcgccgt gaagaagaga tgcggcggca gcaagaagaa atgatgcggc gacagcagga aggattcaag ggaaccttcc ctgatgcgag agagcaggag attcggatgg gtcagatggc tatgggaggt gctatgggca taaacaacag aggtgccatg ccccctgctc ctgtgccagc tggtacccca gctcctccag gacctgccac tatgatgccg gatggaactt tgggattgac cccaccaaca actgaacgct ttggtcaggc tgctacaatg gaaggaattg gggcaattgg tggaactcct cctgcattca accgtgcagc tcctggagct gaatttgccc caaacaaacg tcgccgatac taa
 OMIM    300084
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NONO cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NONO. It may not necessarily be applicable to this product.
 NCBI GI #    40226284
 NCBI GeneID    4841
 NCBI Accession #    BC010049 [Other Products]
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 UniProt Secondary Accession #    O00201; P30807; Q12786; Q9BQC5; B7Z4C2; D3DVV4; F5GYZ3 [Other Products]
 UniProt Related Accession #    Q15233 [Other Products]
 Molecular Weight    43,866 Da
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 NCBI Official Full Name    Homo sapiens non-POU domain containing, octamer-binding, mRNA
 NCBI Official Synonym Full Names    non-POU domain containing, octamer-binding
 NCBI Official Symbol    NONO [Similar Products]
 NCBI Official Synonym Symbols   
P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114
[Similar Products]
 NCBI Protein Information    non-POU domain-containing octamer-binding protein
 UniProt Protein Name    Non-POU domain-containing octamer-binding protein
 UniProt Synonym Protein Names   
54 kDa nuclear RNA- and DNA-binding protein; 55 kDa nuclear protein; DNA-binding p52/p100 complex, 52 kDa subunit; NMT55; p54(nrb); p54nrb
 Protein Family    Non-POU domain-containing octamer-binding protein
 UniProt Gene Name    NONO [Similar Products]
 UniProt Synonym Gene Names    NRB54; NonO protein; p54nrb [Similar Products]
 UniProt Entry Name    NONO_HUMAN
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 NCBI Summary for NONO    This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
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 UniProt Comments for NONO    NONO: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Together with PSPC1, required for the formation of nuclear paraspeckles. A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3.

Protein type: RNA splicing; RNA-binding; Nucleolus; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: membrane; nuclear matrix; nucleoplasm; nucleus; paraspeckles

Molecular Function: chromatin binding; identical protein binding; protein binding

Biological Process: circadian rhythm; mRNA processing; negative regulation of transcription, DNA-dependent; nuclear mRNA splicing, via spliceosome; regulation of circadian rhythm; regulation of transcription, DNA-dependent; RNA splicing

Disease: Mental Retardation, X-linked, Syndromic 34
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 Research Articles on NONO    1. p54(nrb) is a novel regulator of SREBP-1a in the nucleus, and the data suggest that p54(nrb) regulation of SREBP-1a supports the increased cellular demand of lipids for breast cancer growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NONO cdna cloneDiseases associated with NONO cdna clone
 Products by Pathway  Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >19 publications with NONO and Kidney Diseases
 Genital Diseases, Male Antibodies  >9 publications with NONO and Genital Diseases, Male
 Necrosis Antibodies  >9 publications with NONO and Necrosis
 Inflammation Antibodies  >8 publications with NONO and Inflammation
 Edema Antibodies  >4 publications with NONO and Edema
 Prostatic Diseases Antibodies  >4 publications with NONO and Prostatic Diseases
 Immune System Diseases Antibodies  >3 publications with NONO and Immune System Diseases
 Disease Models, Animal Antibodies  >3 publications with NONO and Disease Models, Animal
 Cerebral Infarction Antibodies  >2 publications with NONO and Cerebral Infarction
 Urethral Stricture Antibodies  >1 publications with NONO and Urethral Stricture
Organs/Tissues associated with NONO cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with NONO and Blood
 Kidney Antibodies  >22 publications with NONO and Kidney
 Muscle Antibodies  >16 publications with NONO and Muscle
 Brain Antibodies  >8 publications with NONO and Brain
 Prostate Antibodies  >8 publications with NONO and Prostate
 Heart Antibodies  >7 publications with NONO and Heart
 Bladder Antibodies  >6 publications with NONO and Bladder
 Testis Antibodies  >4 publications with NONO and Testis
 Liver Antibodies  >4 publications with NONO and Liver
 Skin Antibodies  >4 publications with NONO and Skin
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