BC069465
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,876 Da
NCBI Official Full Name
Homo sapiens nitric oxide synthase 3 (endothelial cell), mRNA
NCBI Official Synonym Full Names
nitric oxide synthase 3
NCBI Official Synonym Symbols
NCBI Protein Information
nitric oxide synthase, endothelial
UniProt Protein Name
Nitric oxide synthase, endothelial
UniProt Synonym Protein Names
Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII
UniProt Synonym Gene Names
UniProt Entry Name
NOS3_HUMAN
NCBI Summary for NOS3
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for NOS3
eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.
Protein type: Oxidoreductase; Amino Acid Metabolism - arginine and proline; EC 1.14.13.39
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: caveola; cytoplasm; cytosol; Golgi membrane; nucleus; plasma membrane
Molecular Function: actin monomer binding; heme binding; nitric-oxide synthase activity; protein binding
Biological Process: arginine catabolic process; blood vessel remodeling; cell redox homeostasis; endothelial cell migration; mitochondrion organization and biogenesis; negative regulation of blood pressure; negative regulation of cell proliferation; negative regulation of muscle hyperplasia; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of guanylate cyclase activity; positive regulation of vasodilation; regulation of blood vessel size; regulation of nitric-oxide synthase activity; regulation of systemic arterial blood pressure by endothelin; removal of superoxide radicals; smooth muscle hyperplasia
Disease: Alzheimer Disease; Hypertension, Essential; Preeclampsia/eclampsia 1; Stroke, Ischemic
Research Articles on NOS3
Precautions
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Pathways associated with NOS3 cdna clone
Diseases associated with NOS3 cdna clone
Organs/Tissues associated with NOS3 cdna clone
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