BC003670
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,400 Da
NCBI Official Full Name
Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA
NCBI Official Synonym Full Names
nucleophosmin
NCBI Official Synonym Symbols
NCBI Protein Information
nucleophosmin
UniProt Protein Name
Nucleophosmin
UniProt Synonym Protein Names
Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
UniProt Synonym Gene Names
UniProt Entry Name
NPM_HUMAN
NCBI Summary for NPM1
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniProt Comments for NPM1
NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.
Protein type: Nucleolus; Translation; RNA-binding; Oncoprotein
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole centrosome
Molecular Function: histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding
Biological Process: activation of NF-kappaB transcription factor; cell aging; centrosome cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein localization; protein oligomerization; regulation of centriole replication; regulation of endodeoxyribonuclease activity; response to stress; ribosome assembly
Research Articles on NPM1
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Pathways associated with NPM1 cdna clone
Diseases associated with NPM1 cdna clone
Disease Name |
Pubmed Publications |
Leukemia, Myeloid, Acute Antibodies |
>481 publications with NPM1 and Leukemia, Myeloid, Acute |
Neoplasms Antibodies |
>451 publications with NPM1 and Neoplasms |
Cell Transformation, Neoplastic Antibodies |
>30 publications with NPM1 and Cell Transformation, Neoplastic |
Leukemia, Promyelocytic, Acute Antibodies |
>20 publications with NPM1 and Leukemia, Promyelocytic, Acute |
Carcinoma Antibodies |
>17 publications with NPM1 and Carcinoma |
Adenocarcinoma Antibodies |
>8 publications with NPM1 and Adenocarcinoma |
Breast Neoplasms Antibodies |
>8 publications with NPM1 and Breast Neoplasms |
Neoplasms, Experimental Antibodies |
>5 publications with NPM1 and Neoplasms, Experimental |
Neoplasm Metastasis Antibodies |
>4 publications with NPM1 and Neoplasm Metastasis |
Lung Neoplasms Antibodies |
>4 publications with NPM1 and Lung Neoplasms |
Organs/Tissues associated with NPM1 cdna clone
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