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NPM1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1271714 NPM1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NPM1, cDNA Clone

 Also Known As   

NPM1 cDNA Clone

 Product Gene Name   

NPM1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggaagatt cgatggacat ggacatgagc cccctgaggc cccagaacta tcttttcggt tgtgaactaa aggccgacaa agattatcac tttaaggtgg ataatgatga aaatgagcac cagttatctt taagaacggt cagtttaggg gctggtgcaa aggatgagtt gcacattgtt gaagcagagg caatgaatta cgaaggcagt ccaattaaag taacactggc aactttgaaa atgtctgtac agccaacggt ttcccttggg ggctttgaaa taacaccacc agtggtctta aggttgaagt gtggttcagg gccagtgcat attagtggac agcacttagt agctgtggag gaagatgcag agtcagaaga tgaagaggag gaggatgtga aactcttaag tatatctgga aagcggtctg cccctggagg tggtagcaag gttccacaga aaaaagtaaa acttgctgct gatgaagatg atgacgatga tgatgaagag gatgatgatg aagatgatga tgatgatgat tttgatgatg aggaagctga agaaaaagcg ccagtgaaga aaggacaaga atccttcaag aaacaggaaa aaactcctaa aacaccaaaa ggacctagtt ctgtagaaga cattaaagca aaaatgcaag caagtataga aaaaggtggt tctcttccca aagtggaagc caaattcatc aattatgtga agaattgctt ccggatgact gaccaagagg ctattcaaga tctctggcag tggaggaagt ctctttaa
 OMIM    164040
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NPM1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NPM1. It may not necessarily be applicable to this product.
 NCBI GI #    34190778
 NCBI GeneID    4869
 NCBI Accession #    BC009623 [Other Products]
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 UniProt Secondary Accession #    P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; A8K3N7; B5BU00; D3DQL6 [Other Products]
 UniProt Related Accession #    P06748 [Other Products]
 Molecular Weight    28,400 Da
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 NCBI Official Full Name    Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA
 NCBI Official Synonym Full Names    nucleophosmin
 NCBI Official Symbol    NPM1 [Similar Products]
 NCBI Official Synonym Symbols   
B23; NPM
[Similar Products]
 NCBI Protein Information    nucleophosmin
 UniProt Protein Name    Nucleophosmin
 UniProt Synonym Protein Names   
Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
 Protein Family    Nucleophosmin
 UniProt Gene Name    NPM1 [Similar Products]
 UniProt Synonym Gene Names    NPM; NPM [Similar Products]
 UniProt Entry Name    NPM_HUMAN
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 NCBI Summary for NPM1    This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
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 UniProt Comments for NPM1    NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.

Protein type: Nucleolus; Translation; Oncoprotein; RNA-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole centrosome

Molecular Function: histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding

Biological Process: activation of NF-kappaB transcription factor; cell aging; centrosome cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein localization; protein oligomerization; regulation of centriole replication; regulation of endodeoxyribonuclease activity; response to stress; ribosome assembly
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 Research Articles on NPM1    1. This finding implicates a new role of NPM1 in conveying tumorigenic signals from the BCR-ABL oncoprotein to ribosome biogenesis, affecting cellular growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NPM1 cdna cloneDiseases associated with NPM1 cdna clone
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Interactions Of Rev With Host Cellular Proteins Pathway antibodies  Interactions Of Rev With Host Cellular Proteins Pathway Diagram
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >478 publications with NPM1 and Leukemia, Myeloid, Acute
 Neoplasms Antibodies  >451 publications with NPM1 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >30 publications with NPM1 and Cell Transformation, Neoplastic
 Leukemia, Promyelocytic, Acute Antibodies  >20 publications with NPM1 and Leukemia, Promyelocytic, Acute
 Carcinoma Antibodies  >17 publications with NPM1 and Carcinoma
 Adenocarcinoma Antibodies  >8 publications with NPM1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >8 publications with NPM1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with NPM1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >4 publications with NPM1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >4 publications with NPM1 and Lung Neoplasms
Organs/Tissues associated with NPM1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >179 publications with NPM1 and Blood
 Bone Antibodies  >106 publications with NPM1 and Bone
 Bone Marrow Antibodies  >106 publications with NPM1 and Bone Marrow
 Lung Antibodies  >7 publications with NPM1 and Lung
 Brain Antibodies  >5 publications with NPM1 and Brain
 Skin Antibodies  >4 publications with NPM1 and Skin
 Spleen Antibodies  >4 publications with NPM1 and Spleen
 Heart Antibodies  >3 publications with NPM1 and Heart
 Thyroid Antibodies  >3 publications with NPM1 and Thyroid
 Liver Antibodies  >3 publications with NPM1 and Liver
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