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NR3C1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1277215 NR3C1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR3C1, cDNA Clone

★Popular Item★
 Also Known As   

NR3C1 cDNA Clone

 Product Gene Name   

NR3C1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggactcca aagaatcatt aactcctggt agagaagaaa accccagcag tgtgcttgct caggagaggg gagatgtgat ggacttctat aaaaccctaa gaggaggagc tactgtgaag gtttctgcgt cttcaccctc actggctgtc gcttctcaat cagactccaa gcagcgaaga cttttggttg attttccaaa aggctcagta agcaatgcgc agcagccaga tctgtccaaa gcagtttcac tctcaatggg actgtatatg ggagagacag aaacaaaagt gatgggaaat gacctgggat tcccacagca gggccaaatc agcctttcct cgggggaaac agacttaaag cttttggaag aaagcattgc aaacctcaat aggtcgacca gtgttccaga gaaccccaag agttcagcat ccactgctgt gtctgctgcc cccacagaga aggagtttcc aaaaactcac tctgatgtat cttcagaaca gcaacatttg aagggccaga ctggcaccaa cggtggcaat gtgaaattgt ataccacaga ccaaagcacc tttgacattt tgcaggattt ggagttttct tctgggtccc caggtaaaga gacgaatgag agtccttgga gatcagacct gttgatagat gaaaactgtt tgctttctcc tctggcggga gaagacgatt cattcctttt ggaaggaaac tcgaatgagg actgcaagcc tctcatttta ccggacacta aacccaaaat taaggataat ggagatctgg ttttgtcaag ccccagtaat gtaacactgc cccaagtgaa aacagaaaaa gaagatttca tcgaactctg cacccctggg gtaattaagc aagagaaact gggcacagtt tactgtcagg caagctttcc tggagcaaat ataattggta ataaaatgtc tgccatttct gttcatggtg tgagtacctc tggaggacag atgtaccact atgacatgaa tacagcatcc ctttctcaac agcaggatca gaagcctatt tttaatgtca ttccaccaat tcccgttggt tccgaaaatt ggaataggtg ccaaggatct ggagatgaca acttgacttc tctggggact ctgaacttcc ctggtcgaac agttttttct aatggctatt caagccccag catgagacca gatgtaagct ctcctccatc cagctcctca acagcaacaa caggaccacc tcccaaactc tgcctggtgt gctctgatga agcttcagga tgtcattatg gagtcttaac ttgtggaagc tgtaaagttt tcttcaaaag agcagtggaa ggacagcaca attacctatg tgctggaagg aatgattgca tcatcgataa aattcgaaga aaaaactgcc cagcatgccg ctatcgaaaa tgtcttcagg ctggaatgaa cctggaagct cgaaaaacaa agaaaaaaat aaaaggaatt cagcaggcca ctacaggagt ctcacaagaa acctctgaaa atcctggtaa caaaacaata gttcctgcaa cgttaccaca actcacccct accctggtgt cactgttgga ggttattgaa cctgaagtgt tatatgcagg atatgatagc tctgttccag actcaacttg gaggatcatg actacgctca acatgttagg agggcggcaa gtgattgcag cagtgaaatg ggcaaaggca ataccaggtt tcaggaactt acacctggat gaccaaatga ccctactgca gtactcctgg atgtttctta tggcatttgc tctggggtgg agatcatata gacaatcaag tgcaaacctg ctgtgttttg ctcctgatct gattattaat gagcagagaa tgactctacc ctgcatgtac gaccaatgta aacacatgct gtatgtttcc tctgagttac acaggcttca ggtatcttat gaagagtatc tctgtatgaa aaccttactg cttctctctt cagttcctaa ggacggtctg aagagccaag agctatttga tgaaattaga atgacctaca tcaaagagct aggaaaagcc attgtcaaga gggaaggaaa ctccagccag aactggcagc ggttttatca actgacaaaa ctcttggatt ctatgcatga agtggttgaa aatctcctta actattgctt ccaaacattt ttggataaga ccatgagtat tgaattcccc gagatgttag ctgaaatcat caccaatcag ataccaaaat attcaaatgg aaatatcaaa aaacttctgt ttcatcaaaa gtga
 OMIM    138040
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NR3C1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NR3C1. It may not necessarily be applicable to this product.
 NCBI GI #    33874523
 NCBI GeneID    2908
 NCBI Accession #    BC015610 [Other Products]
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 UniProt Secondary Accession #    P04151; Q53EP5; Q6N0A4; A0ZXF9; B0LPG8; D3DQF4; F5ATB7 [Other Products]
 UniProt Related Accession #    P04150 [Other Products]
 Molecular Weight    49,802 Da
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 NCBI Official Full Name    Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), mRNA
 NCBI Official Synonym Full Names    nuclear receptor subfamily 3 group C member 1
 NCBI Official Symbol    NR3C1 [Similar Products]
 NCBI Official Synonym Symbols   
GR; GCR; GRL; GCCR; GCRST
[Similar Products]
 NCBI Protein Information    glucocorticoid receptor
 UniProt Protein Name    Glucocorticoid receptor
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group C member 1
 Protein Family    Glucocorticoid receptor
 UniProt Gene Name    NR3C1 [Similar Products]
 UniProt Synonym Gene Names    GRL; GR [Similar Products]
 UniProt Entry Name    GCR_HUMAN
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 NCBI Summary for NR3C1    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
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 UniProt Comments for NR3C1    GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.

Protein type: Transcription factor; DNA-binding; Nuclear receptor; Mitochondrial

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cytoplasm; mitochondrial matrix; nucleoplasm; nucleus; protein complex

Molecular Function: glucocorticoid receptor activity; protein binding; protein complex binding; steroid binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Glucocorticoid Resistance, Generalized
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 Research Articles on NR3C1    1. Demonstrate existence of a novel mechanism of GC insensitivity in asthmatics resulting from limited GR nuclear bioavailability as a consequence of decreased baseline GR protein expression and more rapid hormone-induced downregulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NR3C1 cdna cloneDiseases associated with NR3C1 cdna clone
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >15 publications with NR3C1 and Nervous System Diseases
 Inflammation Antibodies  >15 publications with NR3C1 and Inflammation
 Hypertension Antibodies  >15 publications with NR3C1 and Hypertension
 Cardiovascular Diseases Antibodies  >14 publications with NR3C1 and Cardiovascular Diseases
 Depressive Disorder Antibodies  >12 publications with NR3C1 and Depressive Disorder
 Bipolar Disorder Antibodies  >9 publications with NR3C1 and Bipolar Disorder
 Brain Diseases Antibodies  >8 publications with NR3C1 and Brain Diseases
 Muscular Diseases Antibodies  >7 publications with NR3C1 and Muscular Diseases
 Drug Toxicity Antibodies  >7 publications with NR3C1 and Drug Toxicity
 Necrosis Antibodies  >6 publications with NR3C1 and Necrosis
Organs/Tissues associated with NR3C1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >58 publications with NR3C1 and Blood
 Brain Antibodies  >54 publications with NR3C1 and Brain
 Liver Antibodies  >16 publications with NR3C1 and Liver
 Placenta Antibodies  >10 publications with NR3C1 and Placenta
 Heart Antibodies  >8 publications with NR3C1 and Heart
 Nerve Antibodies  >7 publications with NR3C1 and Nerve
 Skin Antibodies  >7 publications with NR3C1 and Skin
 Pituitary Gland Antibodies  >5 publications with NR3C1 and Pituitary Gland
 Adipose Tissue Antibodies  >5 publications with NR3C1 and Adipose Tissue
 Intestine Antibodies  >5 publications with NR3C1 and Intestine
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