BC004904
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,476 Da
NCBI Official Full Name
Homo sapiens nuclear RNA export factor 1, mRNA
NCBI Official Synonym Full Names
nuclear RNA export factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
nuclear RNA export factor 1
UniProt Protein Name
Nuclear RNA export factor 1
UniProt Synonym Protein Names
Tip-associated protein; Tip-associating protein; mRNA export factor TAP
UniProt Synonym Gene Names
UniProt Entry Name
NXF1_HUMAN
NCBI Summary for NXF1
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for NXF1
NXF1: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. Belongs to the NXF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 11q12-q13
Cellular Component: cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function: protein binding; single-stranded RNA binding
Biological Process: mRNA export from nucleus; poly(A)+ mRNA export from nucleus; RNA export from nucleus
Research Articles on NXF1
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Pathways associated with NXF1 cdna clone
Diseases associated with NXF1 cdna clone
Organs/Tissues associated with NXF1 cdna clone
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