View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List OAT cdna clone Catalog # MBS1269144 Unit / Price 0.01 mg Plasmid + 0.2 mL Glycerol-Stock / $205 +1 FREE 8GB USB 5x0.01 mg Plasmid + 5x0.2 mL Glycerol-Stock / $915 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name OAT, cDNA Clone Popular Item Full Product Name OAT cDNA Clone Product Gene Name OAT cdna clone[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence atgttttcca aactagcaca tttgcagagg tttgctgtac ttagtcgcgg agttcattct tcagtggctt ctgctacatc tgttgcaact aaaaaaacag tccaaggccc tccaacctct gatgacattt ttgaaaggga atataagtat ggtgcacaca actaccatcc tttacctgta gccctggaga gaggaaaagg tatttactta tgggatgtag aaggcagaaa atattttgac ttcctgagtt cttacagtgc tgtcaaccaa gggcattgtc accccaagat tgtgaatgct ctgaagagtc aagtggacaa attgacctta acatctagag ctttctataa taacgtactt ggtgaatatg aggagtatat tactaaactt ttcaactacc acaaagttct tcctatgaat acaggagtgg aggctggaga gactgcctgt aaactagctc gtaagtgggg ctataccgtg aagggcattc agaaatacaa agcaaagatt gtttttgcag ctgggaactt ctggggtagg acgttgtctg ctatctccag ttccacagac ccaaccagtt acgatggttt tggaccattt atgccgggat tcgacatcat tccctataat gatctgcccg cactggagcg tgctcttcag gatccaaatg tggctgcgtt catggtagaa ccaattcagg gtgaagcagg cgttgttgtt ccggatccag gttacctaat gggagtgcga gagctctgca ccaggcacca ggttctcttt attgctgatg aaatacagac aggattggcc agaactggta gatggctggc tgttgattat gaaaatgtca gacctgatat agtcctcctt ggaaaggccc tttctggggg cttataccct gtgtctgcag tgctgtgtga tgatgacatc atgctgacca ttaagccagg ggagcatggg tccacatacg gtggcaatcc actaggctgc cgagtggcca tcgcagccct tgaggtttta gaagaagaaa accttgctga aaatgcagac aaattgggca ttatcttgag aaatgaactc atgaagctac cttctgatgt tgtaactgcc gtaagaggaa aaggattatt aaacgctatt gtcattaaag aaaccaaaga ttgggatgct tggaaggtgt gtctacgact tcgagataat ggacttctgg ccaagccaac ccatggcgac attatcaggt ttgcgcctcc gctggtgatc aaggaggatg agcttcgaga gtccattgaa attattaaca agaccatctt gtctttctga OMIM 258870 Vector pENTR223.1 Clone Sequence Report Provided with product shipment ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of OAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP NCBI/Uniprot data below describe general gene information for OAT. It may not necessarily be applicable to this product. NCBI GI # 16877349 NCBI GeneID 4942 NCBI Accession # BC016928 [Other Products] UniProt Secondary Accession # Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03; D3DRF0[Other Products] UniProt Related Accession # P04181[Other Products] Molecular Weight 32,853 Da TOP NCBI Official Full Name Homo sapiens ornithine aminotransferase (gyrate atrophy), mRNA NCBI Official Synonym Full Names ornithine aminotransferase NCBI Official Symbol OAT [Similar Products] NCBI Official Synonym Symbols OKT; GACR; HOGA; OATASE [Similar Products] NCBI Protein Information ornithine aminotransferase, mitochondrial UniProt Protein Name Ornithine aminotransferase, mitochondrial UniProt Synonym Protein Names Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase UniProt Gene Name OAT [Similar Products] UniProt Entry Name OAT_HUMAN TOP NCBI Summary for OAT This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010] TOP UniProt Comments for OAT OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13; MitochondrialChromosomal Location of Human Ortholog: 10q26Cellular Component: mitochondrial matrix; mitochondrionMolecular Function: identical protein binding; ornithine-oxo-acid transaminase activity; pyridoxal phosphate bindingBiological Process: amino acid biosynthetic process; arginine catabolic process to glutamate; arginine catabolic process to proline via ornithine; visual perceptionDisease: Gyrate Atrophy Of Choroid And Retina Research Articles on OAT 1. Sequencing of the gene for ornithine aminotransferase reveals a homozygous mutation in our patient (base exchange c.498C>A in Exon 4). 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TOP Pathways associated with OAT cdna clone Products by Pathway Pathway Diagram Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram Arginine And Proline Metabolism Pathway antibodies Arginine And Proline Metabolism Pathway Diagram Arginine And Proline Metabolism Pathway antibodies Arginine And Proline Metabolism Pathway Diagram Metabolism Pathway antibodies Metabolism Pathway Diagram Metabolism Of Amino Acids And Derivatives Pathway antibodies Metabolism Of Amino Acids And Derivatives Pathway Diagram Urea Cycle And Metabolism Of Amino Groups Pathway antibodies Urea Cycle And Metabolism Of Amino Groups Pathway Diagram Arginine Biosynthesis IV Pathway antibodies Arginine Biosynthesis IV Pathway Diagram Arginine Biosynthesis IV Pathway antibodies Arginine Biosynthesis IV Pathway Diagram Arginine Degradation I (arginase Pathway) antibodies Arginine Degradation I (arginase Pathway) Diagram Arginine Degradation I (arginase Pathway) antibodies Arginine Degradation I (arginase Pathway) Diagram Diseases associated with OAT cdna clone Disease Name Pubmed Publications Neoplasms Antibodies >1249 publications with OAT and Neoplasms Carcinoma Antibodies >1133 publications with OAT and Carcinoma Lung Neoplasms Antibodies >877 publications with OAT and Lung Neoplasms Adenocarcinoma Antibodies >349 publications with OAT and Adenocarcinoma Carcinoma, Squamous Cell Antibodies >285 publications with OAT and Carcinoma, Squamous Cell Cardiovascular Diseases Antibodies >250 publications with OAT and Cardiovascular Diseases Neoplasm Metastasis Antibodies >206 publications with OAT and Neoplasm Metastasis Drug Toxicity Antibodies >157 publications with OAT and Drug Toxicity Heart Diseases Antibodies >110 publications with OAT and Heart Diseases Hyperlipidemias Antibodies >96 publications with OAT and Hyperlipidemias Organs/Tissues associated with OAT cdna clone Organ/Tissue Name Pubmed Publications Lung Antibodies >852 publications with OAT and Lung Blood Antibodies >813 publications with OAT and Blood Liver Antibodies >340 publications with OAT and Liver Intestine Antibodies >272 publications with OAT and Intestine Kidney Antibodies >267 publications with OAT and Kidney Brain Antibodies >223 publications with OAT and Brain Heart Antibodies >127 publications with OAT and Heart Bone Antibodies >121 publications with OAT and Bone Vascular Antibodies >112 publications with OAT and Vascular Skin Antibodies >97 publications with OAT and Skin TOP © 2006-24 MyBioSource.com. 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