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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

OBFC1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275680 OBFC1 cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OBFC1, cDNA Clone

 Also Known As   

OBFC1 cDNA Clone

 Product Gene Name   

OBFC1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    613128
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of OBFC1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for OBFC1. It may not necessarily be applicable to this product.
 NCBI GI #    33869677
 NCBI GeneID    79991
 NCBI Accession #    BC017400 [Other Products]
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 UniProt Secondary Accession #    Q5TCZ0; D3DR99 [Other Products]
 UniProt Related Accession #    Q9H668 [Other Products]
 Molecular Weight    42,119 Da
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 NCBI Official Full Name    Homo sapiens oligonucleotide/oligosaccharide-binding fold containing 1, mRNA
 NCBI Official Synonym Full Names    oligonucleotide/oligosaccharide binding fold containing 1
 NCBI Official Symbol    OBFC1 [Similar Products]
 NCBI Official Synonym Symbols   
STN1; AAF44; AAF-44; RPA-32; bA541N10.2
[Similar Products]
 NCBI Protein Information    CST complex subunit STN1
 UniProt Protein Name    CST complex subunit STN1
 UniProt Synonym Protein Names   
Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog
 Protein Family    CST complex
 UniProt Gene Name    OBFC1 [Similar Products]
 UniProt Synonym Gene Names    STN1 [Similar Products]
 UniProt Entry Name    STN1_HUMAN
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 NCBI Summary for OBFC1    OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
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 UniProt Comments for OBFC1    OBFC1: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Belongs to the STN1 family.

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; single-stranded DNA binding; single-stranded telomeric DNA binding; telomeric DNA binding

Biological Process: negative regulation of telomerase activity; positive regulation of DNA replication; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; telomere maintenance
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 Research Articles on OBFC1    1. we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1). Interestingly, we observed that genetic variation does not account for LTL at birth
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with OBFC1 cdna cloneOrgans/Tissues associated with OBFC1 cdna clone
 Disease Name  Pubmed Publications
 Idiopathic Pulmonary Fibrosis Antibodies  >3 publications with OBFC1 and Idiopathic Pulmonary Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with OBFC1 and Blood
 Lung Antibodies  >3 publications with OBFC1 and Lung
 Heart Antibodies  >2 publications with OBFC1 and Heart
 Prostate Antibodies  >1 publications with OBFC1 and Prostate
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