BC029886
[Other Products]
UniProt Secondary Accession #
Molecular Weight
8,175 Da
NCBI Official Full Name
Homo sapiens occludin, mRNA
UniProt Protein Name
Occludin
UniProt Entry Name
OCLN_HUMAN
UniProt Comments for OCLN
occludin: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. Interacts with TJP1/ZO1 and with VAPA. Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. Belongs to the ELL/occludin family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion
Chromosomal Location of Human Ortholog: 5q13.1
Cellular Component: cell junction; cytoplasmic vesicle; intercellular junction; plasma membrane; tight junction
Molecular Function: protein binding; protein domain specific binding
Biological Process: intercellular junction assembly and maintenance; protein complex assembly
Disease: Band-like Calcification With Simplified Gyration And Polymicrogyria
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Pathways associated with OCLN cdna clone
Diseases associated with OCLN cdna clone
Organs/Tissues associated with OCLN cdna clone
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