BC033826
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,481 Da
NCBI Official Full Name
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 4, mRNA
NCBI Official Synonym Full Names
purinergic receptor P2X 4
NCBI Official Synonym Symbols
NCBI Protein Information
P2X purinoceptor 4
UniProt Protein Name
P2X purinoceptor 4
UniProt Synonym Protein Names
ATP receptor; Purinergic receptor
UniProt Synonym Gene Names
UniProt Entry Name
P2RX4_HUMAN
NCBI Summary for P2RX4
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for P2RX4
P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 12q24.32
Cellular Component: cell junction; integral to nuclear inner membrane; integral to plasma membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: ATP binding; ATP-gated cation channel activity; cadherin binding; copper ion binding; protein binding; purinergic nucleotide receptor activity; receptor binding; zinc ion binding
Biological Process: blood coagulation; endothelial cell activation; membrane depolarization; positive regulation of calcium-mediated signaling; regulation of blood pressure; regulation of sodium ion transport; response to ATP; sensory perception of pain; signal transduction; transport
Research Articles on P2RX4
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Pathways associated with P2RX4 cdna clone
Diseases associated with P2RX4 cdna clone
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