BC109209
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,808 Da
NCBI Official Full Name
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 6, mRNA
NCBI Official Synonym Full Names
purinergic receptor P2X 6
NCBI Protein Information
P2X purinoceptor 6
UniProt Protein Name
P2X purinoceptor 6
UniProt Synonym Protein Names
ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1
UniProt Synonym Gene Names
UniProt Entry Name
P2RX6_HUMAN
NCBI Summary for P2RX6
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]
UniProt Comments for P2RX6
P2X6: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
Protein type: Membrane protein, integral; Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cell junction; cytoplasm; integral to nuclear inner membrane; plasma membrane
Molecular Function: ATP-gated cation channel activity; channel activity; identical protein binding; purinergic nucleotide receptor activity; transmembrane receptor activity
Biological Process: blood coagulation; muscle contraction; protein homooligomerization; signal transduction; transport
Research Articles on P2RX6
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Pathways associated with P2RX6 cdna clone
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