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P2RX7 cdna clone

Scan QR to view Datasheet Catalog #    MBS1278499 P2RX7 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P2RX7, cDNA Clone

★Popular Item★
 Also Known As   

P2RX7 cDNA Clone

 Product Gene Name   

P2RX7 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    602566
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of P2RX7 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for P2RX7. It may not necessarily be applicable to this product.
 NCBI GI #    33877741
 NCBI GeneID    5027
 NCBI Accession #    BC011913 [Other Products]
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 UniProt Secondary Accession #    O14991; Q4VKH8; Q4VKH9; Q4VKI0; Q4VKI1; Q4VKI2; A8K2Z0; E7EMK6; F5H6P2; F5H7E8; F8W951 [Other Products]
 UniProt Related Accession #    Q99572 [Other Products]
 Molecular Weight    58,239 Da
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 NCBI Official Full Name    Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 7, mRNA
 NCBI Official Synonym Full Names    purinergic receptor P2X 7
 NCBI Official Symbol    P2RX7 [Similar Products]
 NCBI Official Synonym Symbols   
P2X7
[Similar Products]
 NCBI Protein Information    P2X purinoceptor 7
 UniProt Protein Name    P2X purinoceptor 7
 UniProt Synonym Protein Names   
ATP receptor; P2Z receptor; Purinergic receptor
 Protein Family    P2X purinoceptor
 UniProt Gene Name    P2RX7 [Similar Products]
 UniProt Synonym Gene Names    P2X7 [Similar Products]
 UniProt Entry Name    P2RX7_HUMAN
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 NCBI Summary for P2RX7    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
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 UniProt Comments for P2RX7    P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.

Protein type: Receptor, misc.; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytoplasm; integral to nuclear inner membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: ATP binding; ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; purinergic nucleotide receptor activity; receptor binding

Biological Process: bleb formation; blood coagulation; cell surface receptor linked signal transduction; membrane depolarization; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phospholipid scrambling; pore complex biogenesis; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization and biogenesis; positive regulation of glycolysis; positive regulation of interleukin-1 beta secretion; regulation of sodium ion transport; response to ATP; sensory perception of pain

Disease: Leukemia, Chronic Lymphocytic
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 Research Articles on P2RX7    1. Report association between elevated expression of P2X7 receptor in monocytes and high serum CRP and cytokine levels in type 2 diabetics.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with P2RX7 cdna cloneDiseases associated with P2RX7 cdna clone
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The NLRP3 Inflammasome Pathway antibodies  The NLRP3 Inflammasome Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >109 publications with P2RX7 and Inflammation
 Neoplasms Antibodies  >78 publications with P2RX7 and Neoplasms
 Nervous System Diseases Antibodies  >76 publications with P2RX7 and Nervous System Diseases
 Disease Models, Animal Antibodies  >51 publications with P2RX7 and Disease Models, Animal
 Necrosis Antibodies  >46 publications with P2RX7 and Necrosis
 Pain Antibodies  >36 publications with P2RX7 and Pain
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >25 publications with P2RX7 and Leukemia, Lymphocytic, Chronic, B-Cell
 Drug Toxicity Antibodies  >22 publications with P2RX7 and Drug Toxicity
 Kidney Diseases Antibodies  >11 publications with P2RX7 and Kidney Diseases
 Nerve Degeneration Antibodies  >10 publications with P2RX7 and Nerve Degeneration
Organs/Tissues associated with P2RX7 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >167 publications with P2RX7 and Blood
 Brain Antibodies  >139 publications with P2RX7 and Brain
 Kidney Antibodies  >50 publications with P2RX7 and Kidney
 Lung Antibodies  >21 publications with P2RX7 and Lung
 Bone Marrow Antibodies  >21 publications with P2RX7 and Bone Marrow
 Skin Antibodies  >16 publications with P2RX7 and Skin
 Liver Antibodies  >9 publications with P2RX7 and Liver
 Spleen Antibodies  >9 publications with P2RX7 and Spleen
 Uterus Antibodies  >9 publications with P2RX7 and Uterus
 Thymus Antibodies  >8 publications with P2RX7 and Thymus
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