BC017062
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,633 Da
NCBI Official Full Name
Homo sapiens prolyl 4-hydroxylase, alpha polypeptide II, mRNA
NCBI Official Synonym Full Names
prolyl 4-hydroxylase subunit alpha 2
NCBI Protein Information
prolyl 4-hydroxylase subunit alpha-2
UniProt Protein Name
Prolyl 4-hydroxylase subunit alpha-2
UniProt Synonym Protein Names
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
UniProt Synonym Gene Names
UniProt Entry Name
P4HA2_HUMAN
NCBI Summary for P4HA2
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for P4HA2
P4HA2: Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Belongs to the P4HA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; EC 1.14.11.2; Secreted, signal peptide; Amino Acid Metabolism - arginine and proline; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; intracellular membrane-bound organelle; nucleus
Molecular Function: electron carrier activity
Research Articles on P4HA2
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Pathways associated with P4HA2 cdna clone
Diseases associated with P4HA2 cdna clone
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