BC015958
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,181 Da
NCBI Official Full Name
Homo sapiens poly(A) binding protein, cytoplasmic 1, mRNA
NCBI Official Synonym Full Names
poly(A) binding protein cytoplasmic 1
NCBI Official Synonym Symbols
PAB1; PABP; PABP1; PABPC2; PABPL1 [Similar Products]
NCBI Protein Information
polyadenylate-binding protein 1
UniProt Protein Name
Polyadenylate-binding protein 1
UniProt Synonym Gene Names
UniProt Entry Name
PABP1_HUMAN
NCBI Summary for PABPC1
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
UniProt Comments for PABPC1
PABP 1: poly(A) binding protein 1. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Shuttles between the cytoplasm and the nucleus. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. A potential substrate in MAPKAP kinase 2-induced mRNA stabilization. Two alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; RNA splicing; RNA-binding; Spliceosome; Translation
Chromosomal Location of Human Ortholog: 8q22.2-q23
Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; nucleus; ribonucleoprotein complex; stress granule
Molecular Function: mRNA 3'-UTR binding; poly(A) binding; poly(U) binding; protein binding; protein C-terminus binding; translation activator activity
Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA polyadenylation; mRNA stabilization; nuclear mRNA splicing, via spliceosome; poly(A) tail shortening; positive regulation of viral genome replication; regulation of mRNA stability; RNA-mediated gene silencing; translational initiation
Research Articles on PABPC1
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Pathways associated with PABPC1 cdna clone
Diseases associated with PABPC1 cdna clone
Organs/Tissues associated with PABPC1 cdna clone
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