BC003016
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,734 Da
NCBI Official Full Name
Homo sapiens platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa, mRNA
NCBI Official Synonym Full Names
platelet activating factor acetylhydrolase 1b catalytic subunit 3
NCBI Official Synonym Symbols
NCBI Protein Information
platelet-activating factor acetylhydrolase IB subunit gamma
UniProt Protein Name
Platelet-activating factor acetylhydrolase IB subunit gamma
UniProt Synonym Protein Names
PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma
UniProt Synonym Gene Names
UniProt Entry Name
PA1B3_HUMAN
NCBI Summary for PAFAH1B3
This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
UniProt Comments for PAFAH1B3
PAFAH1B3: Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain. Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
Protein type: EC 3.1.1.47; Lipase; Lipid Metabolism - ether lipid
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: identical protein binding; phospholipase A2 activity; platelet-activating factor acetyltransferase activity; protein binding
Biological Process: brain development; lipid metabolic process; nervous system development
Research Articles on PAFAH1B3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with PAFAH1B3 cdna clone
Organs/Tissues associated with PAFAH1B3 cdna clone
|