BC017902
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,645 Da
NCBI Official Full Name
Homo sapiens PDZ and LIM domain 5, mRNA
NCBI Official Synonym Full Names
PDZ and LIM domain 5
NCBI Protein Information
PDZ and LIM domain protein 5
UniProt Protein Name
PDZ and LIM domain protein 5
UniProt Synonym Protein Names
Enigma homolog; Enigma-like PDZ and LIM domains protein
UniProt Synonym Gene Names
UniProt Entry Name
PDLI5_HUMAN
NCBI Summary for PDLIM5
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Comments for PDLIM5
LIM: an adaptor protein of the Enigma family. Contains three LIM domains and one PDZ domain. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. Enigma family proteins possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytosol; membrane; postsynaptic density
Molecular Function: actin binding; actinin binding; protein binding; protein kinase C binding
Biological Process: regulation of synaptogenesis
Research Articles on PDLIM5
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Diseases associated with PDLIM5 cdna clone
Organs/Tissues associated with PDLIM5 cdna clone
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