BC032505
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,787 Da
NCBI Official Full Name
Homo sapiens proenkephalin, mRNA
NCBI Official Synonym Full Names
proenkephalin
NCBI Official Synonym Symbols
NCBI Protein Information
proenkephalin-A
UniProt Protein Name
Proenkephalin-A
UniProt Synonym Protein Names
SynenkephalinMet-enkephalinAlternative name(s):Opioid growth factor; OGF
UniProt Synonym Gene Names
UniProt Entry Name
PENK_HUMAN
NCBI Summary for PENK
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
UniProt Comments for PENK
PENK: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. Belongs to the opioid neuropeptide precursor family.
Protein type: Secreted; Secreted, signal peptide; Hormone
Chromosomal Location of Human Ortholog: 8q23-q24
Cellular Component: cell soma; dendrite; extracellular region; nerve terminal; plasma membrane
Molecular Function: neuropeptide hormone activity; opioid receptor binding
Biological Process: neuropeptide signaling pathway; sensory perception; signal transduction; synaptic transmission
Research Articles on PENK
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Pathways associated with PENK cdna clone
Diseases associated with PENK cdna clone
Organs/Tissues associated with PENK cdna clone
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