BC021622
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,465 Da
NCBI Official Full Name
Homo sapiens phosphoinositide-3-kinase, regulatory subunit 3 (gamma), mRNA
NCBI Official Synonym Full Names
phosphoinositide-3-kinase regulatory subunit 3
NCBI Protein Information
phosphatidylinositol 3-kinase regulatory subunit gamma
UniProt Protein Name
Phosphatidylinositol 3-kinase regulatory subunit gamma
UniProt Synonym Protein Names
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK
UniProt Synonym Gene Names
PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma [Similar Products]
UniProt Entry Name
P55G_HUMAN
NCBI Summary for PIK3R3
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
UniProt Comments for PIK3R3
PIK3R3: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Belongs to the PI3K p85 subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: cytosol; phosphoinositide 3-kinase complex
Molecular Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity; protein binding
Biological Process: phosphatidylinositol biosynthetic process; regulation of phosphoinositide 3-kinase activity
Research Articles on PIK3R3
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Pathways associated with PIK3R3 cdna clone
Diseases associated with PIK3R3 cdna clone
Organs/Tissues associated with PIK3R3 cdna clone
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