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PITX2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1266874 PITX2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PITX2, cDNA Clone

★Popular Item★
 Also Known As   

PITX2 cDNA Clone

 Product Gene Name   

PITX2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgaactgca tgaaaggccc gcttcacttg gagcaccgag cagcggggac caagctgtcg gccgtctcct catcttcctg tcaccatccc cagccgttag ccatggcttc ggttctggct cccggtcagc cccggtcgct ggactcctcc aagcacaggc tggaggtgca caccatctcc gacacctcca gcccggaggc cgcagagaaa gataaaagcc agcaggggaa gaatgaggac gtgggcgccg aggacccgtc taagaagaag cggcaaaggc ggcagcggac tcactttacc agccagcagc tccaggagct ggaggccact ttccagagga accgctaccc ggacatgtcc acacgcgaag aaatcgctgt gtggaccaac cttacggaag cccgagtccg ggtttggttc aagaatcgtc gggccaaatg gagaaagagg gagcgcaacc agcaggccga gctatgcaag aatggcttcg ggccgcagtt caatgggctc atgcagccct acgacgacat gtacccaggc tattcctaca acaactgggc cgccaagggc cttacatccg cctccctatc caccaagagc ttccccttct tcaactctat gaacgtcaac cccctgtcat cacagagcat gttttcccca cccaactcta tctcgtccat gagcatgtcg tccagcatgg tgccctcagc agtgacaggc gtcccgggct ccagtctcaa cagcctgaat aacttgaaca acctgagtag cccgtcgctg aattccgcgg tgccgacgcc tgcctgtcct tacgcgccgc cgactcctcc gtatgtttat agggacacgt gtaactcgag cctggccagc ctgagactga aagcaaagca gcactccagc ttcggctacg ccagcgtgca gaacccggcc tccaacctga gtgcttgcca gtatgcagtg gaccggcccg tgtga
 OMIM    137600
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PITX2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PITX2. It may not necessarily be applicable to this product.
 NCBI GI #    40225927
 NCBI GeneID    5308
 NCBI Accession #    BC013998 [Other Products]
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 UniProt Secondary Accession #    O60578; O60579; O60580; Q3KQX9; Q9BY17; A8K6C6; B2RA02; B3KXS0 [Other Products]
 UniProt Related Accession #    Q99697 [Other Products]
 Molecular Weight    30,336 Da
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 NCBI Official Full Name    Homo sapiens paired-like homeodomain 2, mRNA
 NCBI Official Synonym Full Names    paired like homeodomain 2
 NCBI Official Symbol    PITX2 [Similar Products]
 NCBI Official Synonym Symbols   
RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1
[Similar Products]
 NCBI Protein Information    pituitary homeobox 2
 UniProt Protein Name    Pituitary homeobox 2
 UniProt Synonym Protein Names   
ALL1-responsive protein ARP1; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; RIEG bicoid-related homeobox transcription factor; Solurshin
 Protein Family    Pituitary homeobox
 UniProt Gene Name    PITX2 [Similar Products]
 UniProt Synonym Gene Names    ARP1; RGS; RIEG; RIEG1 [Similar Products]
 UniProt Entry Name    PITX2_HUMAN
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 NCBI Summary for PITX2    This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PITX2    PITX2: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo. Defects in PITX2 are the cause of Axenfeld-Rieger syndrome type 1 (RIEG1); also known as Rieger syndrome type 1. RIEG1 is an autosomal dominant defect characterized by hypodontia (partial anodontia), anal stenosis, hypertelorism, mental deficiency, agenesis of the facial bones, with malformation of the anterior chamber of the eye. Defects in PITX2 are the cause of iridogoniodysgenesis type 2 (IRID2); also known as iridogoniodysgenesis syndrome 2 (IGDS2). It is an autosomal dominant inherited disease. Defects in PITX2 are a cause of Peters anomaly (PAN). It is a congenital defect of the anterior chamber of the eye. Defects in PITX2 are associated with ring dermoid of cornea (RDC). RDC is an autosomal dominantly inherited syndrome characterized by bilateral annular limbal dermoids with corneal and conjunctival extension. Belongs to the paired homeobox family. Bicoid subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: nucleus; transcription factor complex

Molecular Function: protein binding; transcription factor activity; transcription factor binding

Biological Process: camera-type eye development; determination of left/right symmetry; hair cell differentiation; odontogenesis; positive regulation of transcription from RNA polymerase II promoter; prolactin secreting cell differentiation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; somatotropin secreting cell differentiation; spleen development

Disease: Axenfeld-rieger Syndrome, Type 1; Iridogoniodysgenesis, Type 2; Peters Anomaly; Ring Dermoid Of Cornea
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 Research Articles on PITX2    1. Expression of PITX2 in BM of early-stage breast cancer patients is associated with risk for early disease recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PITX2 cdna cloneDiseases associated with PITX2 cdna clone
 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >155 publications with PITX2 and Congenital Abnormalities
 Eye Diseases Antibodies  >103 publications with PITX2 and Eye Diseases
 AXENFELD-RIEGER SYNDROME, TYPE 1 Antibodies  >55 publications with PITX2 and AXENFELD-RIEGER SYNDROME, TYPE 1
 Neoplasms Antibodies  >53 publications with PITX2 and Neoplasms
 Abnormalities, Multiple Antibodies  >52 publications with PITX2 and Abnormalities, Multiple
 Heart Defects, Congenital Antibodies  >41 publications with PITX2 and Heart Defects, Congenital
 Tooth Abnormalities Antibodies  >34 publications with PITX2 and Tooth Abnormalities
 Nervous System Diseases Antibodies  >34 publications with PITX2 and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >29 publications with PITX2 and Craniofacial Abnormalities
 Brain Diseases Antibodies  >27 publications with PITX2 and Brain Diseases
Organs/Tissues associated with PITX2 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >1 publications with PITX2 and Placenta
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