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PMS1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1274335 PMS1 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PMS1, cDNA Clone

★Popular Item★
 Also Known As   

PMS1 cDNA Clone

 Product Gene Name   

PMS1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    ATGAAACAAT TGCCTGCGGC AACAGTTCGA CTCCTTTCAA GTTCTCAGAT CATCACTTCG GTGGTCAGTG TTGTAAAAGA GCTTATTGAA AACTCCTTGG ATGCTGGTGC CACAAGCGTA GATGTTAAAC TGGAGAACTA TGGATTTGAT AAAATTGAGG TGCGAGATAA CGGGGAGGGT ATCAAGGCTG TTGATGCACC TGTAATGGCA ATGAAGTACT ACACCTCAAA AATAAATAGT CATGAAGATC TTGAAAATTT GACAACTTAC GGTTTTCGTG GAGAAGCCTT GGGGTCAATT TGTTGTATAG CTGAGGTTTT AATTACAACA AGAACGGCTG CTGATAATTT TAGCACCCAG TATGTTTTAG ATGGCAGTGG CCACATACTT TCTCAGAAAC CTTCACATCT TGGTCAAGGT ACAACTGTAA CTGCTTTAAG ATTATTTAAG AATCTACCTG TAAGAAAGCA GTTTTACTCA ACTGCAAAAA AATGTAAAGA TGAAATAAAA AAGATCCAAG ATCTCCTCAT GAGCTTTGGT ATCCTTAAAC CTGACTTAAG GATTGTCTTT GTACATAACA AGGCAGTTAT TTGGCAGAAA AGCAGAGTAT CAGATCACAA GATGGCTCTC ATGTCAGTTC TGGGGACTGC TGTTATGAAC AATATGGAAT CCTTTCAGTA CCACTCTGAA GAATCTCAGA TTTATCTCAG TGGATTTCTT CCAAAGTGTG ATGCAGACCA CTCTTTCACT AGTCTTTCAA CACCAGAAAG AAGTTTCATC TTCATAAACA GTCGACCAGT ACATCAAAAA GATATCTTAA AGTTAATCCG ACATCATTAC AATCTGAAAT GCCTAAAGGA ATCTACTCGT TTGTATCCTG TTTTCTTTCT GAAAATCGAT GTTCCTACAG CTGATGTTGA TGTAAATTTA ACACCAGATA AAAGCCAAGT ATTATTACAA AATAAGGAAT CTGTTTTAAT TGCTCTTGAA AATCTGATGA CGACTTGTTA TGGACCATTA CCTAGTACAA ATTCTTATGA AAATAATAAA ACAGATGTTT CCGCAGCTGA CATCGTTCTT AGTAAAACAG CAGAAACAGA TGTGCTTTTT AATAAAGTGG AATCATCTGG AAAGAATTAT TCAAATGTTG ATACTTCAGT CATTCCATTC CAAAATGATA TGCATAATGA TGAATCTGGA AAAAACACTG ATGATTGTTT AAATCACCAG ATAAGTATTG GTGACTTTGG TTATGGTCAT TGTAGTAGTG AAATTTCTAA CATTGATAAA AACACTAAGA ATGCATTTCA GGACATTTCA ATGAGTAATG TATCATGGGA GAACTCTCAG ACGGAATATA GTAAAACTTG TTTTATAAGT TCCGTTAAGC ACACCCAGTC AGAAAATGGC AATAAAGACC ATATAGATGA GAGTGGGGAA AATGAGGAAG AAGCAGGTCT TGAAAACTCT TCGGAAATTT CTGCAGATGA GTGGAGCAGG GGAAATATAC TTAAAAATTC AGTGGGAGAG AATATTGAAC CTGTGAAAAT TTTAGTGCCT GAAAAAAGTT TACCATGTAA AGTAAGTAAT AATAATTATC CAATCCCTGA ACAAATGAAT CTTAATGAAG ATTCATGTAA CAAAAAATCA AATGTAATAG ATAATAAATC TGGAAAAGTT ACAGCTTATG ATTTACTTAG CAATCGAGTA ATCAAGAAAC CCATGTCAGC AAGTGCTCTT TTTGTTCAAG ATCATCGTCC TCAGTTTCTC ATAGAAAATC CTAAGACTAG TTTAGAGGAT GCAACACTAC AAATTGAAGA ACTGTGGAAG ACATTGAGTG AAGAGGAAAA ACTGAATCTT TTTAATGGAT CTCATTATTT AGACGTTTTA TATAAAATGA CAGCAGATGA CCAAAGATAC AGTGGATCAA CTTACCTGTC TGATCCTCGT CTTACAGCGA ATGGTTTCAA GATAAAATTG ATACCAGGAG TTTCAATTAC TGAAAATTAA
 OMIM    600258
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PMS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PMS1. It may not necessarily be applicable to this product.
 NCBI GI #    64653334
 NCBI GeneID    5378
 NCBI Accession #    BC096331 [Other Products]
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 UniProt Secondary Accession #    Q4VAL4; Q5FBZ3; Q5FBZ6; Q5FBZ8; D3DPI1 [Other Products]
 UniProt Related Accession #    P54277 [Other Products]
 Molecular Weight    62,919 Da
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 NCBI Official Full Name    Homo sapiens PMS1 postmeiotic segregation increased 1 (S. cerevisiae), mRNA
 NCBI Official Synonym Full Names    PMS1 homolog 1, mismatch repair system component
 NCBI Official Symbol    PMS1 [Similar Products]
 NCBI Official Synonym Symbols   
MLH2; PMSL1; hPMS1; HNPCC3
[Similar Products]
 NCBI Protein Information    PMS1 protein homolog 1
 UniProt Protein Name    PMS1 protein homolog 1
 UniProt Synonym Protein Names   
DNA mismatch repair protein PMS1
 Protein Family    PMS1 protein
 UniProt Gene Name    PMS1 [Similar Products]
 UniProt Synonym Gene Names    PMSL1 [Similar Products]
 UniProt Entry Name    PMS1_HUMAN
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 NCBI Summary for PMS1    This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PMS1    PMS1: Probably involved in the repair of mismatches in DNA. Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3 (HNPCC3). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Belongs to the DNA mismatch repair MutL/HexB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; DNA repair, damage

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: chiasma; MutLalpha complex; nucleus; synaptonemal complex

Molecular Function: ATPase activity; DNA binding; single-stranded DNA binding

Disease: Lynch Syndrome I
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 Research Articles on PMS1    1. Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with PMS1 cdna cloneOrgans/Tissues associated with PMS1 cdna clone
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >97 publications with PMS1 and Neoplasms
 Ovarian Neoplasms Antibodies  >10 publications with PMS1 and Ovarian Neoplasms
 Drug Toxicity Antibodies  >7 publications with PMS1 and Drug Toxicity
 Breast Neoplasms Antibodies  >6 publications with PMS1 and Breast Neoplasms
 Anemia Antibodies  >4 publications with PMS1 and Anemia
 Death Antibodies  >4 publications with PMS1 and Death
 Immune System Diseases Antibodies  >4 publications with PMS1 and Immune System Diseases
 Kidney Diseases Antibodies  >3 publications with PMS1 and Kidney Diseases
 Hyperplasia Antibodies  >2 publications with PMS1 and Hyperplasia
 Anemia, Hemolytic Antibodies  >2 publications with PMS1 and Anemia, Hemolytic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with PMS1 and Blood
 Kidney Antibodies  >5 publications with PMS1 and Kidney
 Lung Antibodies  >5 publications with PMS1 and Lung
 Prostate Antibodies  >5 publications with PMS1 and Prostate
 Skin Antibodies  >5 publications with PMS1 and Skin
 Stomach Antibodies  >4 publications with PMS1 and Stomach
 Bone Antibodies  >3 publications with PMS1 and Bone
 Pancreas Antibodies  >3 publications with PMS1 and Pancreas
 Intestine Antibodies  >3 publications with PMS1 and Intestine
 Brain Antibodies  >3 publications with PMS1 and Brain
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