BC014449
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,485 Da
NCBI Official Full Name
Homo sapiens patatin-like phospholipase domain containing 3, mRNA
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 3
NCBI Protein Information
patatin-like phospholipase domain-containing protein 3
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 3
UniProt Synonym Protein Names
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
UniProt Synonym Gene Names
UniProt Entry Name
PLPL3_HUMAN
NCBI Summary for PNPLA3
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for PNPLA3
PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - tyrosine; EC 3.1.1.3; Lipid Metabolism - glycerolipid; Transferase; Membrane protein, integral; Phospholipase; Amino Acid Metabolism - phenylalanine; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane
Molecular Function: acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity
Biological Process: lipid homeostasis; triacylglycerol biosynthetic process; triacylglycerol catabolic process
Research Articles on PNPLA3
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Pathways associated with PNPLA3 cdna clone
Diseases associated with PNPLA3 cdna clone
Organs/Tissues associated with PNPLA3 cdna clone
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