BC033202
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,194 Da
NCBI Official Full Name
Homo sapiens peter pan homolog (Drosophila), mRNA
NCBI Official Synonym Full Names
peter pan homolog (Drosophila)
NCBI Protein Information
suppressor of SWI4 1 homolog; suppressor of sterile four 1; homolog of S. cerevisiae SSF1; second-step splicing factor 1; brix domain-containing protein 3
UniProt Protein Name
Suppressor of SWI4 1 homolog
UniProt Synonym Protein Names
Brix domain-containing protein 3; Peter Pan homolog
UniProt Synonym Gene Names
UniProt Entry Name
SSF1_HUMAN
NCBI Summary for PPAN
The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
UniProt Comments for PPAN
SSF1: May have a role in cell growth. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Nucleolus
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: nucleolus; nucleus
Biological Process: RNA splicing
Research Articles on PPAN
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Pathways associated with PPAN cdna clone
Diseases associated with PPAN cdna clone
Organs/Tissues associated with PPAN cdna clone
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