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QARS cdna clone

Scan QR to view Datasheet Catalog #    MBS1278839 QARS cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

QARS, cDNA Clone

 Also Known As   


 Product Gene Name   

QARS cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    603727
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of QARS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for QARS. It may not necessarily be applicable to this product.
 NCBI GI #    16741668
 NCBI GeneID    5859
 NCBI Accession #    BC016634 [Other Products]
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 UniProt Secondary Accession #    B4DWJ2 [Other Products]
 UniProt Related Accession #    P47897 [Other Products]
 Molecular Weight    86,579 Da
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 NCBI Official Full Name    Homo sapiens glutaminyl-tRNA synthetase, mRNA
 NCBI Official Synonym Full Names    glutaminyl-tRNA synthetase
 NCBI Official Symbol    QARS [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    glutamine--tRNA ligase
 UniProt Protein Name    Glutamine--tRNA ligase
 UniProt Synonym Protein Names   
Glutaminyl-tRNA synthetase; GlnRS
 UniProt Gene Name    QARS [Similar Products]
 UniProt Synonym Gene Names    GlnRS [Similar Products]
 UniProt Entry Name    SYQ_HUMAN
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 NCBI Summary for QARS    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
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 UniProt Comments for QARS    QARS: catalyzes the formation of L-glutaminyl-tRNA. Belongs to the class-I aminoacyl-tRNA synthetase family.

Protein type: EC; Mitochondrial; Translation; Ligase

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion

Molecular Function: glutamine-tRNA ligase activity; protein binding; RNA binding

Biological Process: brain development; glutaminyl-tRNA aminoacylation; tRNA aminoacylation for protein translation

Disease: Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy
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 Research Articles on QARS    1. Data indicate compound heterozygous mutations [c.169T>C (p.Tyr57His) and c.1485dup (p.Lys496*)] in QARS, which encodes glutaminyl-tRNA synthetase, in two siblings with early-onset epileptic encephalopathy (EOEE).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with QARS cdna cloneDiseases associated with QARS cdna clone
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with QARS and Brain Diseases
 Neoplasms Antibodies  >1 publications with QARS and Neoplasms
 Drug Toxicity Antibodies  >1 publications with QARS and Drug Toxicity
 Cardiovascular Diseases Antibodies  >1 publications with QARS and Cardiovascular Diseases
Organs/Tissues associated with QARS cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with QARS and Brain
 Spinal Cord Antibodies  >1 publications with QARS and Spinal Cord
 Nerve Antibodies  >1 publications with QARS and Nerve
 Muscle Antibodies  >1 publications with QARS and Muscle
 Kidney Antibodies  >1 publications with QARS and Kidney
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