BC015350
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,015 Da
NCBI Official Full Name
Homo sapiens queuine tRNA-ribosyltransferase 1, mRNA
NCBI Official Synonym Full Names
queuine tRNA-ribosyltransferase catalytic subunit 1
NCBI Protein Information
queuine tRNA-ribosyltransferase
UniProt Protein Name
Queuine tRNA-ribosyltransferase
UniProt Synonym Protein Names
Guanine insertion enzyme; tRNA-guanine transglycosylase
UniProt Synonym Gene Names
UniProt Entry Name
TGT_HUMAN
NCBI Summary for QTRT1
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
UniProt Comments for QTRT1
QTRT1: Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). Belongs to the queuine tRNA-ribosyltransferase family.
Protein type: RNA processing; EC 2.4.2.29; Transferase; Mitochondrial
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; mitochondrial outer membrane
Molecular Function: protein heterodimerization activity; protein homodimerization activity; queuine tRNA-ribosyltransferase activity
Biological Process: queuosine biosynthetic process; tRNA modification
Research Articles on QTRT1
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Pathways associated with QTRT1 cdna clone
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