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RASGRF1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1277366 RASGRF1 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RASGRF1, cDNA Clone

 Also Known As   

RASGRF1 cDNA Clone

 Product Gene Name   

RASGRF1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    606600
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RASGRF1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for RASGRF1. It may not necessarily be applicable to this product.
 NCBI GI #    25955553
 NCBI GeneID    5923
 NCBI Accession #    BC040275 [Other Products]
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 UniProt Secondary Accession #    Q16027; F8VPA5; H0YKF2; J3KQP9 [Other Products]
 UniProt Related Accession #    Q13972 [Other Products]
 Molecular Weight    143,218 Da
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 NCBI Official Full Name    Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1, mRNA
 NCBI Official Synonym Full Names    Ras protein specific guanine nucleotide releasing factor 1
 NCBI Official Symbol    RASGRF1 [Similar Products]
 NCBI Official Synonym Symbols   
GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1
[Similar Products]
 NCBI Protein Information    ras-specific guanine nucleotide-releasing factor 1
 UniProt Protein Name    Ras-specific guanine nucleotide-releasing factor 1
 UniProt Synonym Protein Names   
Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide exchange factor CDC25
 Protein Family    Ras-specific guanine nucleotide-releasing factor
 UniProt Gene Name    RASGRF1 [Similar Products]
 UniProt Synonym Gene Names    CDC25; GNRP; GRF1; Ras-GRF1; GNRP [Similar Products]
 UniProt Entry Name    RGRF1_HUMAN
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 NCBI Summary for RASGRF1    The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
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 UniProt Comments for RASGRF1    RASGRF1: a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported.

Protein type: GEFs; GEFs, Ras

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: cytosol; growth cone; plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: MAPKKK cascade; neurite development; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of synaptic plasticity; signal transduction
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 Research Articles on RASGRF1    1. Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RASGRF1 cdna cloneDiseases associated with RASGRF1 cdna clone
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with RASGRF1 and Nervous System Diseases
 Memory Disorders Antibodies  >4 publications with RASGRF1 and Memory Disorders
 Learning Disorders Antibodies  >3 publications with RASGRF1 and Learning Disorders
 Drug Toxicity Antibodies  >3 publications with RASGRF1 and Drug Toxicity
 Weight Loss Antibodies  >2 publications with RASGRF1 and Weight Loss
 Dyskinesia, Drug-Induced Antibodies  >2 publications with RASGRF1 and Dyskinesia, Drug-Induced
 Inflammation Antibodies  >2 publications with RASGRF1 and Inflammation
 Weight Gain Antibodies  >2 publications with RASGRF1 and Weight Gain
 Refractive Errors Antibodies  >2 publications with RASGRF1 and Refractive Errors
 Myopia Antibodies  >2 publications with RASGRF1 and Myopia
Organs/Tissues associated with RASGRF1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >86 publications with RASGRF1 and Brain
 Blood Antibodies  >16 publications with RASGRF1 and Blood
 Embryonic Tissue Antibodies  >15 publications with RASGRF1 and Embryonic Tissue
 Nerve Antibodies  >12 publications with RASGRF1 and Nerve
 Kidney Antibodies  >8 publications with RASGRF1 and Kidney
 Pancreas Antibodies  >5 publications with RASGRF1 and Pancreas
 Eye Antibodies  >4 publications with RASGRF1 and Eye
 Placenta Antibodies  >4 publications with RASGRF1 and Placenta
 Lung Antibodies  >4 publications with RASGRF1 and Lung
 Spleen Antibodies  >2 publications with RASGRF1 and Spleen
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