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RB1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270982 RB1 cdna clone
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 Product Name   

RB1, cDNA Clone

★Popular Item★
 Also Known As   

RB1 cDNA Clone

 Product Gene Name   

RB1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    109800
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RB1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for RB1. It may not necessarily be applicable to this product.
 NCBI GI #    24660139
 NCBI GeneID    5925
 NCBI Accession #    BC039060 [Other Products]
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 UniProt Secondary Accession #    P78499; Q5VW46; Q8IZL4; A8K5E3 [Other Products]
 UniProt Related Accession #    P06400 [Other Products]
 Molecular Weight    106,159 Da
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 NCBI Official Full Name    Homo sapiens retinoblastoma 1, mRNA
 NCBI Official Synonym Full Names    RB transcriptional corepressor 1
 NCBI Official Symbol    RB1 [Similar Products]
 NCBI Official Synonym Symbols   
RB; pRb; OSRC; pp110; p105-Rb; PPP1R130
[Similar Products]
 NCBI Protein Information    retinoblastoma-associated protein
 UniProt Protein Name    Retinoblastoma-associated protein
 UniProt Synonym Protein Names   
p105-Rb; pRb; Rb; pp110
 Protein Family    RB1-inducible coiled-coil protein
 UniProt Gene Name    RB1 [Similar Products]
 UniProt Synonym Gene Names    Rb [Similar Products]
 UniProt Entry Name    RB_HUMAN
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 NCBI Summary for RB1    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RB1    Rb: retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression.

Protein type: Tumor suppressor; Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: chromatin; nucleoplasm; nucleus; PML body; Rb-E2F complex; SWI/SNF complex; transcription elongation factor complex b

Molecular Function: DNA binding; identical protein binding; kinase binding; phosphoprotein binding; protein binding; transcription factor activity; transcription factor binding; ubiquitin protein ligase binding

Biological Process: cell cycle arrest; cell cycle checkpoint; chromatin remodeling; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; maintenance of mitotic sister chromatid cohesion; mitotic cell cycle checkpoint; myoblast differentiation; negative regulation of protein kinase activity; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter, mitotic; negative regulation of transcription, DNA-dependent; positive regulation of mitotic metaphase/anaphase transition; Ras protein signal transduction; regulation of lipid kinase activity; regulation of mitotic cell cycle; sister chromatid biorientation

Disease: Bladder Cancer; Osteogenic Sarcoma; Retinoblastoma; Small Cell Cancer Of The Lung
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 Research Articles on RB1    1. Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RB1 cdna cloneDiseases associated with RB1 cdna clone
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1161 publications with RB1 and Neoplasms
 Retinoblastoma Antibodies  >966 publications with RB1 and Retinoblastoma
 Carcinoma Antibodies  >252 publications with RB1 and Carcinoma
 Breast Neoplasms Antibodies  >111 publications with RB1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >102 publications with RB1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >77 publications with RB1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >70 publications with RB1 and Neoplasms, Experimental
 Osteosarcoma Antibodies  >64 publications with RB1 and Osteosarcoma
 Drug Toxicity Antibodies  >59 publications with RB1 and Drug Toxicity
 Liver Diseases Antibodies  >48 publications with RB1 and Liver Diseases
Organs/Tissues associated with RB1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >252 publications with RB1 and Blood
 Eye Antibodies  >208 publications with RB1 and Eye
 Brain Antibodies  >173 publications with RB1 and Brain
 Lung Antibodies  >112 publications with RB1 and Lung
 Bone Antibodies  >91 publications with RB1 and Bone
 Liver Antibodies  >87 publications with RB1 and Liver
 Muscle Antibodies  >74 publications with RB1 and Muscle
 Skin Antibodies  >50 publications with RB1 and Skin
 Intestine Antibodies  >49 publications with RB1 and Intestine
 Prostate Antibodies  >46 publications with RB1 and Prostate
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