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RBBP4 cdna clone

Scan QR to view Datasheet Catalog #    MBS1276988 RBBP4 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RBBP4, cDNA Clone

 Also Known As   

RBBP4 cDNA Clone

 Product Gene Name   

RBBP4 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggccgaca aggaagcagc cttcgacgac gcagtggaag aacgagtgat caacgaggaa tacaaaatat ggaaaaagaa cacccctttt ctttatgatt tggtgatgac ccatgctctg gagtggccca gcctaactgc ccagtggctt ccagatgtaa ccagaccaga agggaaagat ttcagcattc atcgacttgt cctggggaca cacacatcgg atgaacaaaa ccatcttgtt atagccagtg tgcagctccc taatgatgat gctcagtttg atgcgtcaca ctacgacagt gagaaaggag aatttggagg ttttggttca gttagtggaa aaattgaaat agaaatcaag atcaaccatg aaggagaagt aaacagggcc cgttatatgc cccagaaccc ttgtatcatc gcaacaaaga ctccttccag tgatgttctt gtctttgact atacaaaaca tccttctaaa ccagatcctt ctggagagtg caacccagac ttgcgtctcc gtggacatca gaaggaaggc tatgggcttt cttggaaccc aaatctcagt gggcacttac ttagtgcttc agatgaccat accatctgcc tgtgggacat cagtgccgtt ccaaaggagg gaaaagtggt agatgcgaag accatcttta cagggcatac ggcagtagta gaagatgttt cctggcatct actccatgag tctctgtttg ggtcagttgc tgatgatcag aaacttatga tttgggatac tcgttcaaac aatacttcca aacccagcca ctcagttgat gctcacactg ctgaagtgaa ctgcctttct ttcaatcctt atagtgagtt cattcttgcc acaggatcag ctgacaagac tgttgccttg tgggatctga gaaatctgaa acttaagttg cattcctttg agtcacataa ggatgaaata ttccaggttc agtggtcacc tcacaatgag actattttag cttccagtgg tactgatcgc agactgaatg tctgggattt aagtaaaatt ggagaggaac aatccccaga agatgcagaa gacgggccac cagagttgtt gtttattcat ggtggtcata ctgccaagat atctgatttc tcctggaatc ccaatgaacc ttgggtgatt tgttctgtat cagaagacaa tatcatgcaa gtgtggcaaa tggcagagaa catttataat gatgaagacc ctgaaggaag cgtggatcca gaaggacaag ggtcctag
 OMIM    602923
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RBBP4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for RBBP4. It may not necessarily be applicable to this product.
 NCBI GI #    13111850
 NCBI GeneID    5928
 NCBI Accession #    BC003092 [Other Products]
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 UniProt Secondary Accession #    P31149; Q53H02; Q96BV9; B2R6G9; B4DRH0; D3DPQ3 [Other Products]
 UniProt Related Accession #    Q09028 [Other Products]
 Molecular Weight    43,482 Da
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 NCBI Official Full Name    Homo sapiens retinoblastoma binding protein 4, mRNA
 NCBI Official Synonym Full Names    RB binding protein 4, chromatin remodeling factor
 NCBI Official Symbol    RBBP4 [Similar Products]
 NCBI Official Synonym Symbols   
NURF55; RBAP48; lin-53
[Similar Products]
 NCBI Protein Information    histone-binding protein RBBP4
 UniProt Protein Name    Histone-binding protein RBBP4
 UniProt Synonym Protein Names   
Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48
 Protein Family    Histone-binding protein
 UniProt Gene Name    RBBP4 [Similar Products]
 UniProt Synonym Gene Names    RBAP48; CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; RBBP-4 [Similar Products]
 UniProt Entry Name    RBBP4_HUMAN
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 NCBI Summary for RBBP4    This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for RBBP4    RBBP4: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Interacts with SUV39H1 and HDAC7. Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the PRC2/EED- EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with SPEN/MINT. Interacts with BRCA1. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: ESC/E(Z) complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex

Molecular Function: DNA-dependent ATPase activity; histone deacetylase activity; histone deacetylase binding; nucleosomal DNA binding; protein binding

Biological Process: ATP-dependent chromatin remodeling; chromatin assembly; chromatin remodeling; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; negative regulation of cell proliferation; negative regulation of gene expression, epigenetic; regulation of cell cycle
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 Research Articles on RBBP4    1. RBBP4 functions as a novel regulatory factor to increase the efficiency of importin alpha/beta-mediated nuclear import
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RBBP4 cdna cloneDiseases associated with RBBP4 cdna clone
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 G0 And Early G1 Pathway antibodies  G0 And Early G1 Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Mitotic G1-G1/S Phases Pathway antibodies  Mitotic G1-G1/S Phases Pathway Diagram
 Nucleosome Assembly Pathway antibodies  Nucleosome Assembly Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with RBBP4 and Neoplasms
 Carcinoma Antibodies  >7 publications with RBBP4 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with RBBP4 and Adenocarcinoma
 Liver Diseases Antibodies  >2 publications with RBBP4 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with RBBP4 and Liver Neoplasms
 Necrosis Antibodies  >2 publications with RBBP4 and Necrosis
 Breast Neoplasms Antibodies  >2 publications with RBBP4 and Breast Neoplasms
 Skin Diseases Antibodies  >2 publications with RBBP4 and Skin Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with RBBP4 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >1 publications with RBBP4 and Neoplasms, Experimental
Organs/Tissues associated with RBBP4 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with RBBP4 and Blood
 Salivary Gland Antibodies  >3 publications with RBBP4 and Salivary Gland
 Mouth Antibodies  >2 publications with RBBP4 and Mouth
 Liver Antibodies  >2 publications with RBBP4 and Liver
 Lymph Antibodies  >1 publications with RBBP4 and Lymph
 Muscle Antibodies  >1 publications with RBBP4 and Muscle
 Thymus Antibodies  >1 publications with RBBP4 and Thymus
 Thyroid Antibodies  >1 publications with RBBP4 and Thyroid
 Placenta Antibodies  >1 publications with RBBP4 and Placenta
 Ovary Antibodies  >1 publications with RBBP4 and Ovary
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