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RSPO2 cdna clone

Scan QR to view Datasheet Catalog #    MBS1272438 RSPO2 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RSPO2, cDNA Clone

★Popular Item★
 Also Known As   

RSPO2 cDNA Clone

 Product Gene Name   

RSPO2 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgcgccagt atggagagtg cctgcattcc tgcccatccg ggtactatgg acaccgagcc ccagatatga acagatgtgc aagatgcaga atagaaaact gtgattcttg ctttagcaaa gacttttgta ccaagtgcaa agtaggcttt tatttgcata gaggccgttg ctttgatgaa tgtccagatg gttttgcacc attagaagaa accatggaat gtgtggaagg atgtgaagtt ggtcattgga gcgaatgggg aacttgtagc agaaataatc gcacatgtgg atttaaatgg ggtctggaaa ccagaacacg gcaaattgtt aaaaagccag tgaaagacac aataccgtgt ccaaccattg ctgaatccag gagatgcaag atgacaatga ggcattgtcc aggagggaag agaacaccaa aggcgaagga gaagaggaac aagaaaaaga aaaggaagct gatagaaagg gcccaggagc aacacagcgt cttcctagct acagacagag ctaaccaata a
 OMIM    610575
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RSPO2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for RSPO2. It may not necessarily be applicable to this product.
 NCBI GI #    20380782
 NCBI GeneID    340419
 NCBI Accession #    BC027938 [Other Products]
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 UniProt Secondary Accession #    Q4G0U4; Q8N6X6; B3KVP0 [Other Products]
 UniProt Related Accession #    Q6UXX9 [Other Products]
 Molecular Weight    20,972 Da
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 NCBI Official Full Name    Homo sapiens R-spondin 2 homolog (Xenopus laevis), mRNA
 NCBI Official Synonym Full Names    R-spondin 2
 NCBI Official Symbol    RSPO2 [Similar Products]
 NCBI Official Synonym Symbols   
CRISTIN2
[Similar Products]
 NCBI Protein Information    R-spondin-2
 UniProt Protein Name    R-spondin-2
 UniProt Synonym Protein Names   
Roof plate-specific spondin-2; hRspo2
 Protein Family    R-spondin
 UniProt Gene Name    RSPO2 [Similar Products]
 UniProt Synonym Gene Names    hRspo2 [Similar Products]
 UniProt Entry Name    RSPO2_HUMAN
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 NCBI Summary for RSPO2    This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for RSPO2    R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: extracellular region

Molecular Function: protein binding; receptor binding
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 Research Articles on RSPO2    1. data reveal a RSPO2-induced, LGR5-dependent Wnt signaling-negative feedback loop that exerts a net growth-suppressive effect on CRC cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with RSPO2 cdna cloneOrgans/Tissues associated with RSPO2 cdna clone
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with RSPO2 and Neoplasms
 Nervous System Diseases Antibodies  >1 publications with RSPO2 and Nervous System Diseases
 Carcinoma Antibodies  >1 publications with RSPO2 and Carcinoma
 Hyperplasia Antibodies  >1 publications with RSPO2 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with RSPO2 and Lung
 Muscle Antibodies  >3 publications with RSPO2 and Muscle
 Embryonic Tissue Antibodies  >2 publications with RSPO2 and Embryonic Tissue
 Blood Antibodies  >2 publications with RSPO2 and Blood
 Ear Antibodies  >1 publications with RSPO2 and Ear
 Skin Antibodies  >1 publications with RSPO2 and Skin
 Testis Antibodies  >1 publications with RSPO2 and Testis
 Intestine Antibodies  >1 publications with RSPO2 and Intestine
 Brain Antibodies  >1 publications with RSPO2 and Brain
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