BC000632
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,471 Da
NCBI Official Full Name
Homo sapiens S100 calcium binding protein A13, mRNA
NCBI Official Synonym Full Names
S100 calcium binding protein A13
NCBI Protein Information
protein S100-A13
UniProt Protein Name
Protein S100-A13
UniProt Synonym Protein Names
S100 calcium-binding protein A13
UniProt Entry Name
S10AD_HUMAN
NCBI Summary for S100A13
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for S100A13
S100A13: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine. Belongs to the S-100 family.
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cytosol; extracellular space; nucleus; perinuclear region of cytoplasm
Molecular Function: calcium ion binding; copper ion binding; fibroblast growth factor binding; protein binding; protein homodimerization activity; RAGE receptor binding; zinc ion binding
Biological Process: cytokine secretion; interleukin-1 alpha secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade
Research Articles on S100A13
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Diseases associated with S100A13 cdna clone
Organs/Tissues associated with S100A13 cdna clone
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