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S100A8 cdna clone

Scan QR to view Datasheet Catalog #    MBS1276065 S100A8 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100A8, cDNA Clone

 Also Known As   

S100A8 cDNA Clone

 Product Gene Name   

S100A8 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgttgaccg agctggagaa agccttgaac tctatcatcg acgtctacca caagtactcc ctgataaagg ggaatttcca tgccgtctac agggatgacc tgaagaaatt gctagagacc gagtgtcctc agtatatcag gaaaaagggt gcagacgtct ggttcaaaga gttggatatc aacactgatg gtgcagttaa cttccaggag ttcctcattc tggtgataaa gatgggcgtg gcagcccaca aaaaaagcca tgaagaaagc cacaaagagt ag
 OMIM    123885
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of S100A8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for S100A8. It may not necessarily be applicable to this product.
 NCBI GI #    34782940
 NCBI GeneID    6279
 NCBI Accession #    BC005928 [Other Products]
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 UniProt Secondary Accession #    Q5SY70; Q9UC84; Q9UC92; Q9UCJ0; Q9UCM6; A8K5L3; D3DV37 [Other Products]
 UniProt Related Accession #    P05109 [Other Products]
 Molecular Weight    10,835 Da
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 NCBI Official Full Name    Homo sapiens S100 calcium binding protein A8, mRNA
 NCBI Official Synonym Full Names    S100 calcium binding protein A8
 NCBI Official Symbol    S100A8 [Similar Products]
 NCBI Official Synonym Symbols   
P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG
[Similar Products]
 NCBI Protein Information    protein S100-A8
 UniProt Protein Name    Protein S100-A8
 UniProt Synonym Protein Names   
Calgranulin-A; Calprotectin L1L subunit; Cystic fibrosis antigen; CFAG
 Protein Family    Protein
 UniProt Gene Name    S100A8 [Similar Products]
 UniProt Synonym Gene Names    CAGA; CFAG; MRP8; CFAG; MRP-8; p8 [Similar Products]
 UniProt Entry Name    S10A8_HUMAN
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 NCBI Summary for S100A8    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
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 UniProt Comments for S100A8    S100A8: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF- kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Belongs to the S-100 family.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoskeleton; cytosol; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: arachidonic acid binding; calcium ion binding; microtubule binding; protein binding; RAGE receptor binding; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; autophagy; caspase activation; chemokine production; cytokine production; defense response to bacterium; defense response to fungus; inflammatory response; leukocyte migration during inflammatory response; neutrophil chemotaxis; peptidyl-cysteine S-nitrosylation; positive regulation of cell growth; positive regulation of inflammatory response; regulation of cytoskeleton organization and biogenesis; sequestering of zinc ion
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 Research Articles on S100A8    1. BBP exposure also increased tumor infiltrating myeloid-derived suppressor cell (MDSC) secretion of S100A8/A9, thereby exacerbating the resistance of breast cancer to doxorubicin with cyclophosphamide
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with S100A8 cdna cloneOrgans/Tissues associated with S100A8 cdna clone
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >318 publications with S100A8 and Inflammation
 Neoplasms Antibodies  >181 publications with S100A8 and Neoplasms
 Skin Diseases Antibodies  >102 publications with S100A8 and Skin Diseases
 Fibrosis Antibodies  >90 publications with S100A8 and Fibrosis
 Disease Models, Animal Antibodies  >69 publications with S100A8 and Disease Models, Animal
 Necrosis Antibodies  >67 publications with S100A8 and Necrosis
 Cardiovascular Diseases Antibodies  >56 publications with S100A8 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >49 publications with S100A8 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >35 publications with S100A8 and Carcinoma, Squamous Cell
 Brain Diseases Antibodies  >33 publications with S100A8 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >412 publications with S100A8 and Blood
 Skin Antibodies  >110 publications with S100A8 and Skin
 Lung Antibodies  >87 publications with S100A8 and Lung
 Vascular Antibodies  >74 publications with S100A8 and Vascular
 Bone Antibodies  >54 publications with S100A8 and Bone
 Bone Marrow Antibodies  >43 publications with S100A8 and Bone Marrow
 Brain Antibodies  >42 publications with S100A8 and Brain
 Muscle Antibodies  >34 publications with S100A8 and Muscle
 Liver Antibodies  >33 publications with S100A8 and Liver
 Heart Antibodies  >30 publications with S100A8 and Heart
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