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S100B cdna clone

Scan QR to view Datasheet Catalog #    MBS1270359 S100B cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100B, cDNA Clone

★Popular Item★
 Also Known As   

S100B cDNA Clone

 Product Gene Name   

S100B cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgtctgagc tggagaaggc catggtggcc ctcatcgacg ttttccacca atattctgga agggagggag acaagcacaa gctgaagaaa tccgaactca aggagctcat caacaatgag ctttcccatt tcttagagga aatcaaagag caggaggttg tggacaaagt catggaaaca ctggacaatg atggagacgg cgaatgtgac ttccaggaat tcatggcctt tgttgccatg gttactactg cctgccacga gttctttgaa catgagtga
 OMIM    176990
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of S100B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for S100B. It may not necessarily be applicable to this product.
 NCBI GI #    12804680
 NCBI GeneID    6285
 NCBI Accession #    BC001766 [Other Products]
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 UniProt Secondary Accession #    D3DSN6 [Other Products]
 UniProt Related Accession #    P04271 [Other Products]
 Molecular Weight    10,713 Da
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 NCBI Official Full Name    Homo sapiens S100 calcium binding protein B, mRNA
 NCBI Official Synonym Full Names    S100 calcium binding protein B
 NCBI Official Symbol    S100B [Similar Products]
 NCBI Official Synonym Symbols   
NEF; S100; S100-B; S100beta
[Similar Products]
 NCBI Protein Information    protein S100-B
 UniProt Protein Name    Protein S100-B
 UniProt Synonym Protein Names   
S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
 Protein Family    Protein
 UniProt Gene Name    S100B [Similar Products]
 UniProt Entry Name    S100B_HUMAN
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 NCBI Summary for S100B    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for S100B    S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; extracellular region; intracellular membrane-bound organelle; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity; RAGE receptor binding; tau protein binding; zinc ion binding

Biological Process: axonogenesis; cell proliferation; central nervous system development; innate immune response; learning and/or memory; positive regulation of I-kappaB kinase/NF-kappaB cascade
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 Research Articles on S100B    1. There was no association found between serum and CSF S100B with radiographic vasospasm or DIND. S100B is a potential prognostic marker for aSAH outcome
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with S100B cdna cloneDiseases associated with S100B cdna clone
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DAI Mediated Induction Of Type I IFNs Pathway antibodies  DAI Mediated Induction Of Type I IFNs Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >521 publications with S100B and Nervous System Diseases
 Brain Diseases Antibodies  >431 publications with S100B and Brain Diseases
 Cardiovascular Diseases Antibodies  >197 publications with S100B and Cardiovascular Diseases
 Brain Injuries Antibodies  >151 publications with S100B and Brain Injuries
 Growth Disorders Antibodies  >127 publications with S100B and Growth Disorders
 Inflammation Antibodies  >107 publications with S100B and Inflammation
 Brain Ischemia Antibodies  >99 publications with S100B and Brain Ischemia
 Disease Models, Animal Antibodies  >93 publications with S100B and Disease Models, Animal
 Heart Diseases Antibodies  >52 publications with S100B and Heart Diseases
 Necrosis Antibodies  >42 publications with S100B and Necrosis
Organs/Tissues associated with S100B cdna clone
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >925 publications with S100B and Nerve
 Brain Antibodies  >740 publications with S100B and Brain
 Blood Antibodies  >584 publications with S100B and Blood
 Heart Antibodies  >89 publications with S100B and Heart
 Skin Antibodies  >47 publications with S100B and Skin
 Eye Antibodies  >27 publications with S100B and Eye
 Lung Antibodies  >26 publications with S100B and Lung
 Spinal Cord Antibodies  >18 publications with S100B and Spinal Cord
 Embryonic Tissue Antibodies  >14 publications with S100B and Embryonic Tissue
 Connective Tissue Antibodies  >8 publications with S100B and Connective Tissue
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